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Penta-EF-Hand (PEF) Proteins and Calsenilin/DREAM: Involvement of the New EF-Hand Calcium-Binding Proteins in Apoptosis and Signal Transduction

  • Masatoshi Maki

Abstract

Calcium ions control a variety of cellular phenomena, including muscle contraction, adhesion, secretion, motility, growth, differentiation, gene expression, etc. Alterations in intracellular Ca2+ homeostasis are also commonly observed during apoptosis or programmed cell death by various stimuli such as glucocorticoid treatment, Interleukin-3 withdrawal, T cell receptor cross-linking, Fas/CD95 stimulation and oxidative stress (see reviews by McConkey and Orrenius, 1997, by Krebs, 1998, and references therein). The duration and extent of Ca2+ influx may determine whether cells survive, die by apoptosis or undergo necrosis. Ca2+-binding proteins are the mediators of the signals, and play pivotal roles in the above-mentioned cellular phenomena through a variety of different mechanisms.

Keywords

Ryanodine Receptor PXXP Motif Dominant Negative Protein Prodynorphin Gene Downstream Regulatory Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2000

Authors and Affiliations

  • Masatoshi Maki
    • 1
  1. 1.Department of Applied Molecular Biosciences, Graduate School of Bioagricultural SciencesNagoya UniversityJapan

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