Ryanodine-Sensitive Calcium Release Channels

  • Daniela Rossi
  • Virginia Barone
  • Ilenia Simeoni
  • Vincenzo Sorrentino


Variations in the intracellular calcium concentration [Ca2+] i play an important role in a variety of intracellular processes, including secretion, contraction and cell proliferation (Berridge, 1993). Increases in [Ca2+] i can be exerted by an influx of ions from the extracellular medium and/or by a release of Ca2+ from intracellular stores. Two classes of intracellular channels that play a key role in regulating Ca2+ release from intracellular stores have been so far identified: the inositol 1,4,5-trisphosphate (InsP3) receptors and the Ryanodine Receptors (RyRs) (Berridge, 1993; Sorrentino and Volpe, 1993). InsP3 receptors are described in Parys et al. (this book). This chapter will focus on the second class of intracellular Ca2+ release channels: the Ryanodine Receptors.


Skeletal Muscle Sarcoplasmic Reticulum Release Channel Ryanodine Receptor Granular Cell Layer 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Daniela Rossi
    • 1
  • Virginia Barone
    • 2
  • Ilenia Simeoni
    • 1
  • Vincenzo Sorrentino
    • 1
    • 2
  1. 1.Section of Molecular Medicine, Department of NeurosciencesUniversity of SienaItaly
  2. 2.DIBITIstituto Scientifico San RaffaeleMilanItaly

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