Abstract
Molecules that function as linear templates are promising tools for gaining control of chemical reactivity that approaches the nanometer-scale level, and beyond (i.e. > 10 Å) [1,2]. Such molecules possess an ability to deliberately juxtapose, and, in doing so, force two reactant molecules in position for reaction. Such control of reactivity is achieved, similar to proteins and DNA [1], by way of molecular assembly processes involving noncovalent forces (e.g. hydrogen bonds), which enables reactions to proceed with regio- and stereocontrol not displayed by an individual reactant molecule.
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Macgillivray, L.R. (2002). Controlling Molecular Synthesis in the Solid State Using Linear Templates. In: Domenicano, A., Hargittai, I. (eds) Strength from Weakness: Structural Consequences of Weak Interactions in Molecules, Supermolecules, and Crystals. NATO Science Series, vol 68. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0546-3_19
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DOI: https://doi.org/10.1007/978-94-010-0546-3_19
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