Abstract
Laser-induced phase-separation polymerization of a porous acrylate polymer is used for in-situ fabrication of dialysis membranes inside glass microchannels. A shaped 355 nm laser beam is used to define polymer membranes of 4–14 μm thickness, which bond to the glass microchannel and form a semipermeable membrane. Differential diffusion through the membrane is observed for fluorescein molecules versus 200 nm latex microspheres, showing the potential for this technique to integrate sample cleanup into chip-based analysis systems.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
N. Xu, Y. Lin, S.A. Hofstadler, D. Matson, C.J. Call, R.D.A. Smith, Anal Chem 70 (1998).
J. Lichtenberg, N.F. de Rooij, E. Verpoorte, Talanta 56 (2002).
C. Yu, M.H. Davey, F. Svec, J.M.J. Frechet, Anal Chem 73 (2001).
D.J. Throckmorton, T.J. Shepodd, A.K. Singh, Anal Chem 74 (2002).
B.J. Kirby, T.J. Shepodd, E.F. Hasselbrink, J. Chrom A, in press (2002).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media Dordrecht
About this paper
Cite this paper
Kirby, B.J., Singh, A.K. (2002). In-situ Fabrication of Dialysis Membranes in Glass Microchannels Using Laser-induced Phase-Separation Polymerization. In: Baba, Y., Shoji, S., van den Berg, A. (eds) Micro Total Analysis Systems 2002. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0504-3_47
Download citation
DOI: https://doi.org/10.1007/978-94-010-0504-3_47
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-3953-6
Online ISBN: 978-94-010-0504-3
eBook Packages: Springer Book Archive