Abstract
We have developed a microfluidic chip for single-cell analysis and drug screening. The proposed device consists of surface-modified silicon channels capped with a grooved PDMS cover layer. Some region of the channel surface is treated to be hydrophobic for air leak during drug injection. We have demonstrated that the proposeded device can provide self-controlled single-cell isolation/positioning and independent drug injection onto the captured single-cell.
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© 2002 Springer Science+Business Media Dordrecht
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Yun, KS., Lee, SI., Lee, G.M., Yoon, E. (2002). Design and Fabrication of Micro/Nano-Fluidic Chip Performing Single-Cell Positioning and Nanoliter Drug Injection for Single-Cell Analysis. In: Baba, Y., Shoji, S., van den Berg, A. (eds) Micro Total Analysis Systems 2002. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0504-3_17
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DOI: https://doi.org/10.1007/978-94-010-0504-3_17
Publisher Name: Springer, Dordrecht
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