Abstract
The paper reports on three key technologies that have enabled the development of a wearable flow cytometer: flow sensing and control based on low-power MEMS-based sensors/actuators; microfluidic processing based on miniaturized disposable plastic cartridges; and optical detection based on arrays of solid-state lasers/detectors and integrated micro-optics. This instrument can provide early detection of viral and bacterial infections based on quick (30 seconds) measurement of lymphocyte and neutrophil counts [1]. Personnel with little or no medical training can use this low-cost, low-maintenance instrument in doctor’s offices, homes, and public/private-sector facilities. Multiparameter scattering-based or fluorescence-based cytometers can be developed based on this technology for clinical, industrial and military applications.
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References
[http://www.darpa.mil/MTO/bioflips/presentations/2001-l/index.html [DARPA BioFlips Program]
Cabuz, E., et al., “MEMS-based flow controller for flow cytometery,” Proceedings Hilton Head 2002: Solid-State Sensor, Actuator and Microsystems Workshop, June 2–6, 2002, Hilton Head Island, South Carolina, pp. 110–111.
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© 2002 Springer Science+Business Media Dordrecht
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Cabuz, C. et al. (2002). Enabling Technologies for a Personal Flow Cytometer (Part I). In: Baba, Y., Shoji, S., van den Berg, A. (eds) Micro Total Analysis Systems 2002. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0504-3_15
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DOI: https://doi.org/10.1007/978-94-010-0504-3_15
Publisher Name: Springer, Dordrecht
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