Abstract
For several years we have investigated the preparation of compounds which mimic β-turn secondary structures that are intrinsic to certain protein-protein interactions and that are therefore able to effect antigen-antibody and ligand-receptor relationships. We have shown in our third and fourth generation β-turn mimetics that they express activity in targets such as opioid receptors and in GPCRs [1–3]. Based on the fourth generation template, we have applied similar procedures used in the production of our β-sheet libraries [4] to generate libraries based on the template shown below.
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Dattilo, J. et al. (2001). Synthesis of Combinatorial Libraries Associated with Constrained β-Turn Mimetics. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_89
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DOI: https://doi.org/10.1007/978-94-010-0464-0_89
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