Abstract
Mono-benzyl phosphate esters of Fmoc protected phosphoamino acids, Fmoc-Aaa(PO(OBzl)OH)-OH (Aaa = Ser, Thr, Tyr), are extremely valuable tools for the synthesis of phosphopeptides by Fmoc SPPS methods [1]. However, a recent report [2] has indicated that the use of standard activation methods with these derivatives can lead to poor yields. In this poster, the development of an optimized coupling protocol and its application in the synthesis of multiphosphorylated peptides is described.
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References
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© 2001 Springer Science+Business Media Dordrecht
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White, P. (2001). Optimization of Coupling Methods for the Introduction of Mono-Benzyl Phosphate Esters of Fmoc Protected Phosphoamino Acids. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_42
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DOI: https://doi.org/10.1007/978-94-010-0464-0_42
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-3905-5
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