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Biaryl-Bridged Lipopeptides from Streptomyces sp. TÜ 6075

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Peptides: The Wave of the Future

Abstract

HPLC-DAD screening for new metabolites [1] from Streptomyces sp. TÜ 6075 revealed two series of compounds composed of five colorless and seven yellow fractions. For structure elucidation, ES-FTICR-MS, chiral GC-MS, Edman sequencing, and NMR spectroscopy were used. The isolated compounds, termed arylomycins, represent the first example of lipopeptides containing biaryl-bridged amino acids. The majority of the arylomycins exhibit antimicrobial activity against Gram-positive bacteria.

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References

  1. Fiedler, H.-P. Nat. Prod. Lett. 2, 119 (1993).

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  2. Vaisar, T., Urban, J. J. Mass Spectrom. 33, 505 (1998).

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© 2001 Springer Science+Business Media Dordrecht

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Schmid, D.G. et al. (2001). Biaryl-Bridged Lipopeptides from Streptomyces sp. TÜ 6075. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_359

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  • DOI: https://doi.org/10.1007/978-94-010-0464-0_359

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3905-5

  • Online ISBN: 978-94-010-0464-0

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