Abstract
Corticotropin Releasing Factor (CRF) is an important physiological regulator of the body response to stressful stimuli [1]. Over-expression of CRF is involved in endocrine, neurologic and psychiatric diseases such as feeding disorders, major depression and anxiety-related disorders. To obtain more insight into the physiological role of CRF, potent peptide antagonists have recently been developed mainly based on the amino acid sequence of CRF, which ultimately led to the discovery of astressin, one of the most potent peptide-based CRF antagonists reported until now [2].
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Rijkers, D.T.S., den Hartog, J.A.J., Liskamp, R.M.J. WO 0129086.
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Rijkers, D.T.S., den Hartog, J.A.J., Liskamp, R.M.J. (2001). Structure-Activity Studies on the Corticotropin Releasing Factor Antagonist Astressin, Minimal Sequence Necessary for Antagonistic Activity: Implications for a New Pharmacophoric Model. In: Lebl, M., Houghten, R.A. (eds) Peptides: The Wave of the Future. American Peptide Symposia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0464-0_339
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DOI: https://doi.org/10.1007/978-94-010-0464-0_339
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