Development of a Human Growth Hormone Peptide Analogue AOD9604 into an Anti-Obesity Drug

Abstract

Previous studies from our laboratory have identified that a carboxy-terminal fragment of the human growth hormone (hGH), hGH(177–191), is the lipolytic/anti-lipogenic domain of intact hGH [1]. By targeting the key enzymes involved in lipid metabolism, hGH(177–191) is able to increase lipolysis, and decrease lipogenesis in adipose tissue, resulting in reduction of body weight gain in obese rodent models. In view of its significant clinical potential, the aim of our study is to develop the peptide into a drug for the treatment of human obesity. A series of peptide analogues of hGH(177–191) were designed, synthesized and studied for the structure-activity relationship.

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