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Dynamics of Actin Filaments in Motility Assays

A microscopic model and its numerical simulation

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Book cover Structure and Dynamics of Confined Polymers

Part of the book series: NATO Science Series ((ASHT,volume 87))

Abstract

We investigate a microscopic model of in-vitro motility assays in which actin filaments slide over a layer of myosin heads attached to a glass plate. The resulting set of Langevin equations is solved, and the numerical results are compared to those observed in the related experiments. The agreement is very good, suggesting that our model can predict the behavior under modified conditions or determine some of the parameters that cannot be measured directly, by finding the best fit to the experimentally observed quantities.

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Author information

Authors and Affiliations

  1. Dept. of Biological Physics, Eötvös University, P. Box 32, Budapest, 1518, Hungary

    Zeno Farkas

  2. Collegium Budapest / Institute for Advanced Studies, Szentháromság u. 2, Budapest, 1114, Hungary

    Zeno Farkas & Tomas Vicsek

  3. Dept. of Surgery MC 6035, University of Chicago, Chicago, IL, 60637, USA

    Imre Derényi

Authors
  1. Zeno Farkas
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  2. Imre Derényi
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  3. Tomas Vicsek
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Editor information

Editors and Affiliations

  1. Biotechnology Division, National Institute of Standards and Technology, Gaithersburg, USA

    John J. Kasianowicz

  2. Department of Biophysics, Pécs University Medical School, Pécs, Hungary

    Miklós S. Z. Kellermayer

  3. Biophysics Laboratory, Department of Chemistry and Biochemistry, University of California, Santa Cruz, USA

    David W. Deamer

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© 2002 Springer Science+Business Media Dordrecht

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Farkas, Z., Derényi, I., Vicsek, T. (2002). Dynamics of Actin Filaments in Motility Assays. In: Kasianowicz, J.J., Kellermayer, M.S.Z., Deamer, D.W. (eds) Structure and Dynamics of Confined Polymers. NATO Science Series, vol 87. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0401-5_20

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  • DOI: https://doi.org/10.1007/978-94-010-0401-5_20

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-0698-2

  • Online ISBN: 978-94-010-0401-5

  • eBook Packages: Springer Book Archive

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