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Anti-Tumor Activity of Noguchi Catalyser 21™, a Mineral Water Containing Natural Leaf Soil

  • Chapter
Animal Cell Technology: From Target to Market

Part of the book series: ESACT Proceedings ((ESACT,volume 1))

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Abstract

We evaluated anti-tumor activity of Noguchi Catalyser 21− (Catalyser). Effect of Catalyser was examined on the tumor growth derived from ras/SFME cells transplanted into BALB/c mice. By oral free administration of Catalyser, suppression of the tumor growth was observed since 5th week of tumor transplantation and maximally about 25% at 7th week in comparison with tap water. Furthermore, in order to elucidate this effect cytologically, we evaluated the production of anti-tumor cytokines. RT-PCR analysis revealed that the transcription of IL-12 p40 subunit was significantly enhanced in murine macrophage cell line J774-1, RAW264 and BALB/c mouse-derived peritoneal cavity macrophage. This suggests that enhancement of the tumor immune systems via IL-12 production may be enhanced by Catalyser.

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References

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Author information

Authors and Affiliations

  1. Department of Genetic Resources Technology, Kyushu University, Fukuoka, 812-8581, Japan

    T. Kawahara, K. Teruya, Y. Katakura & S. Shirahata

  2. Noguchi General Laboratory Co. Ltd., 4-5-8 Tsunehisa, Miyazaki, 880-0913, Japan

    H. Takada

Authors
  1. T. Kawahara
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  2. K. Teruya
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  3. Y. Katakura
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  4. H. Takada
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  5. S. Shirahata
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Editor information

Editors and Affiliations

  1. Metcon Medicin AB, Dalenum 17, Lidingö, Sweden

    Elisabeth Lindner-Olsson

  2. Biovitrum AB, Lindhagensgatan 133, 112 76, Stockholm, Sweden

    Nathalie Chatzissavidou

  3. Astra Zeneca, Building 841, 151 85, Södertälje, Sweden

    Elke Lüllau

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© 2001 Springer Science+Business Media Dordrecht

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Kawahara, T., Teruya, K., Katakura, Y., Takada, H., Shirahata, S. (2001). Anti-Tumor Activity of Noguchi Catalyser 21™, a Mineral Water Containing Natural Leaf Soil. In: Lindner-Olsson, E., Chatzissavidou, N., Lüllau, E. (eds) Animal Cell Technology: From Target to Market. ESACT Proceedings, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0369-8_3

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  • DOI: https://doi.org/10.1007/978-94-010-0369-8_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3897-3

  • Online ISBN: 978-94-010-0369-8

  • eBook Packages: Springer Book Archive

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