Abstract
Ammonia is a key factor in the pathogenesis of hepatic encephalopathy (HE), which is a major complication of acute and chronic liver failure. Signs of HE are highly variable and range from mild personality changes to deep coma, but, at any level of severity, HE is potentially reversible (for reviews see1–4). The molecular mechanisms underlying ammonia neurotoxicity are incompletely understood. However, that altered astrocytic function critically contributes to ammonia neurotoxicity is beyond doubt.2,5
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Schliess, F. et al. (2003). Astroglial protein tyrosine nitration by ammonia. In: Jones, E.A., Meijer, A.J., Chamuleau, R.A.F.M. (eds) Encephalopathy and Nitrogen Metabolism in Liver Failure. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0159-5_29
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DOI: https://doi.org/10.1007/978-94-010-0159-5_29
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