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Protein Secretion in Gram-Positive Bacteria

  • Chapter
Protein Secretion Pathways in Bacteria

Abstract

Studies on protein secretion in Gram-positive bacteria have become of particular importance since many species are of great commercial value and medical interest. Several Gram-positive bacteria have been applied successfully for cost-effective industrial production of enzymes since, due to the absence of an outer membrane, proteins are secreted directly into the growth medium from which they can be easily purified. In addition, the study of the protein secretion repertoire of Gram-positives has contributed to our fundamental understanding of notorious pathogens, such as Staphylococcus aureus, and may facilitate the rational design of novel drugs, specifically targeted against these organisms (Alksne et al., 2000).

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7. References

  • Alksne, L.E., Burgio, P., Hu, W., Feld, B., Singh, M.P., Tuckman, M., Petersen, P.J., Labthavikul, P., McGlynn, M., Barbieri, L., McDonald, L., Bradford, P., Dushin, R.G., Rothstein, D., and Projan S.J. (2000) Antimicrob Agents Chemother 44: 1418–1427.

    Article  PubMed  CAS  Google Scholar 

  • Altamura, N., Capitanio, N., Bonnefoy, N., Papa, S., and Dujardin, G. (1996) FEBS Lett 382: 111–115.

    Article  PubMed  CAS  Google Scholar 

  • Andersen, C.L., Matthey-Dupraz, A., Missiakas, D., and Raina, S. (1997) Mol Microbiol 26: 121–132.

    Article  PubMed  CAS  Google Scholar 

  • Antelmann, H., Tjalsma, H., Voigt, B., Ohlmeier, S., Bron, S., van Dijl, J.M., Hecker, M., (2001) Genome Research 11: 1484–1502.

    Article  PubMed  CAS  Google Scholar 

  • Bauer, M., Behrens, M., Esser, K., Michaelis, G., and Pratje, E. (1994) Mol Gen Genet 245: 272–278.

    Article  PubMed  CAS  Google Scholar 

  • Berks, B.C., Sargent, F., and Palmer, T. (2000) Mol Microbiol 5: 260–274.

    Article  Google Scholar 

  • Bibi, E. (1998) Trends Biochem Sci 23:51–55.

    Article  PubMed  CAS  Google Scholar 

  • Bogsch, E., Sargent, F., Stanly, N.R., Berks, B.C., Robinson, C., and Palmer, T. (1998) J Biol Chem 273: 18003–18006.

    Article  PubMed  CAS  Google Scholar 

  • Bolhuis, A., Broekhuizen, C.P., Sorokin, A., van Roosmalen, M.L., Venema, G., Bron, S., Quax, W.J., and van Dijl, J.M. (1998) J Biol Chem 273: 21217–21224.

    Article  PubMed  CAS  Google Scholar 

  • Bolhuis, A., Matzen, A., Hyyrylaïnen, H.L., Kontinen, V.P., Meima, R., Chapuis, J., Venema, G., Bron, S., Freudl, R., and van Dijl, J.M. (1999) J Biol Chem 274: 24585–24592.

    Article  PubMed  CAS  Google Scholar 

  • Bolhuis, A., Venema, G., Quax, W.J., Bron, S., and van Dijl, J.M. (1999a) J Biol Chem 274: 24531–24538.

    Article  PubMed  CAS  Google Scholar 

  • Bolotin, A., Wincker, P., Mauger, S., Jaillon, O., Malarme, K., Weissenbach, J., Ehrlich, S.D. and Sorokin, A. (2001) Genome Res 11: 731–753.

    Article  PubMed  CAS  Google Scholar 

  • Braunstein, M., Brown. A.M., Kurtz, S., and Jacobs, W.R. (2001) J Bacteriol 183: 6979–6990.

    Article  PubMed  CAS  Google Scholar 

  • Bron, S., Meima, R., van Dijl, J.M., Wipat, A., and Harwood, C. (1999) In: A.L. Demain, and E. Davies (eds), Manual of industrial microbiology and biotechnology (2nd edition), ASM press, Washington, D.C., pp. 392–416.

    Google Scholar 

  • Bunai, K., Yamada, K., Hayashi, K., Nakamura, K., and Yamane, K. (1999) J Biochem (Tokyo) 125:151–159.

    Article  CAS  Google Scholar 

  • Carpenter, P.B., Hanlon, D.W., and Ordal, G.W. (1992) Mol Microbiol 6: 2705–2713.

    Article  PubMed  CAS  Google Scholar 

  • Chen, M., and Nagarajan, V., (1994) J Bacteriol 176: 5796–5801.

    PubMed  CAS  Google Scholar 

  • Chung, Y.J., Steen, M.T., and Hansen, J.N. (1992) J Bacteriol 174: 1417–1422.

    PubMed  CAS  Google Scholar 

  • Chung, Y.S., Breidt, F., and Dubnau, D. (1998) Mol Microbiol 29: 905–913.

    Article  PubMed  CAS  Google Scholar 

  • Cregg, K.M., Wilding, I., and Black, M.T. (1996) J Bacteriol 178: 5712–5718.

    PubMed  CAS  Google Scholar 

  • Cristóbal, S., de Gier, J.W., Nielsen, H., and von Heijne, G. (1999) EMBO J 18: 2982–2990.

    Article  PubMed  Google Scholar 

  • Dalbey, R.E., and Robinson, C. (1999) Trends Biochem Sci 24: 17–22.

    Article  PubMed  CAS  Google Scholar 

  • de Leeuw, E. (2000) Thesis, Vrije Universiteit Amsterdam, The Netherlands

    Google Scholar 

  • de Leeuw, E., te Kaat, K., Moser, C., Menestrina, G., Demel, R., de Kruijff, B., Oudega, B., Luirink, J., and Sinning, I., (2000) EMBO J 19:531–541.

    Article  PubMed  Google Scholar 

  • Driessen, A.J.M., Fekkes, P., and van der Wolk, J.P. (1998) Curr Opin Microbiol 1: 216–222.

    Article  PubMed  CAS  Google Scholar 

  • Dubnau, D., and Lovett, C.M. (2001) In: A. L. Sonenshein, J. A. Hoch, and R. Losick (eds.), Bacillus subtilis and its closest relatives: from genes to cells. American Society for Microbiology, Washington, D.C., pp. 453–471.

    Google Scholar 

  • Dumoulin, A. (2000) Genbank, acc.nr. AAG41993.

    Google Scholar 

  • Errington, J., Appleby, L., Danie, R.A., Goodfellow, H., Partridge, S.R., and Yudkin, M.D. (1992) J Gen Microbiol 138:2609–2618.

    Article  PubMed  CAS  Google Scholar 

  • Eichler, J., and Moll, R. (2001) Trends Microbiol 9: 130–136.

    Article  PubMed  CAS  Google Scholar 

  • Feilmeier, B.J., Iseminger, G., Schroeder, D., Webber, H., Phillips, G.J. (2000) J Bacteriol 182:4068–4076.

    Article  PubMed  CAS  Google Scholar 

  • Fekkes, P., and Driessen, A.J.M. (1999) Microbiol Mol Biol Rev 63: 161–173.

    PubMed  CAS  Google Scholar 

  • Ferrari, E., Jarnagin, A. S., and Schmidt, B. F. (1993) In: A. L. Sonenshein, J. A. Hoch, and R. Losick (eds.), Bacillus subtilis and other gram-positive bacteria. American Society for Microbiology, Washington, D.C., pp. 917–937.

    Google Scholar 

  • Foster, S.J., and Popham. D.L. (2001) In: A. L. Sonenshein, J. A. Hoch, and R. Losick (eds.), Bacillus subtilis and its closest relatives: from genes to cells. American Society for Microbiology, Washington, D.C., pp. 21–41.

    Google Scholar 

  • Haandrikman, A.J., Kok, J., and Venema, G. (1991a) J Bacteriol 173: 4517–4525.

    PubMed  CAS  Google Scholar 

  • Haandrikman A.J, Meesters R, Laan H, Konings WN, Kok J, Venema G (1991b) Appl Environ Microbiol 57: 1899–1904.

    PubMed  CAS  Google Scholar 

  • Havarstein, L.S., Diep, D.B., and Nes, I.F. (1995) Mol Microbiol 16: 229–240.

    Article  PubMed  CAS  Google Scholar 

  • Hell, K., Herrmann, J.M., Pratje, E., Neupert, W., and Stuart, R.A. (1998) Proc Natl Acad Sci USA 95: 2250–2255.

    Article  PubMed  CAS  Google Scholar 

  • Hell, K., Neupert, W., and Stuart, R.A. (2001) EMBO J 20: 1281–1288.

    Article  PubMed  CAS  Google Scholar 

  • Herbort, M., Klein, M., Manting, E.H., Driessen, A.J., and Freudl, R. (1999) J Bacteriol 181: 493–500.

    PubMed  CAS  Google Scholar 

  • Herskovits, A.A., Bochkareva, E.S., and Bibi, E. (2000) Mol Microbiol 38: 927–939.

    Article  PubMed  CAS  Google Scholar 

  • Hirose, I., Sano, K., Shioda, I., Kumano, M., Nakamura, K., and Yamane, K. (2000) Microbiology 146: 65–75.

    PubMed  CAS  Google Scholar 

  • Houben, E.N.G., Scotti, P.A., Valent, Q.A., Brunner, J., de Gier J.-W.L., Oudega, B., and Luirink, J. (2000) FEBS Lett 476: 229–233.

    Article  PubMed  CAS  Google Scholar 

  • Hynds, P.J., Robinson, D., and Robinson, C. (1998) J Biol Chem 273: 34868–34874.

    Article  PubMed  CAS  Google Scholar 

  • Hyyryläinen, H.L., Vitikainen, M., Thwaite, J., Wu, H., Sarvas, M., Harwood, C.R., Kontinen, V.P., and Stephenson, K. (2000) J Biol Chem 275: 26696–26703.

    PubMed  Google Scholar 

  • Ishihara, T., Tomita, H., Hasegawa, Y., Tsukagoshi, N., Yamagata, H., and Udaka, S. (1995) J Bacteriol 177: 745–749.

    PubMed  CAS  Google Scholar 

  • Jacobs, M., Andersen, J.B., Kontinen, V.P., and Sarvas, M. (1993) Mol Microbiol 8: 957–966.

    Article  PubMed  CAS  Google Scholar 

  • Jeong, S.M., Yoshikawa, H., and Takahashi, H. (1993) Mol Microbiol 10: 133–142.

    Article  PubMed  CAS  Google Scholar 

  • Jongbloed, J.D.H., Martin, U., Antelmann, H., Hecker, M., Tjalsma, H., Venema, G., Bron, S., van Dijl, J.M., and Müller, J. (2000) J Biol Chem 275: 41350–41357.

    Article  PubMed  CAS  Google Scholar 

  • Kakeshita, H., Oguro, A., Amikura, R., Nakamura, K., and Yamane, K. (2000) Microbiol 146:2595–2603.

    CAS  Google Scholar 

  • Kaneko, T., Sato, S., Kotani, H., Tanaka, A., Asamizu, E., Nakamura, Y. Miyajima, N., Hirosawa, M., Sugiura, M., Sasamoto, S., Kimura, T., Hosouchi, T., Matsuno, A., Muraki, A., Nakazaki, N., Naruo, K., Okumura, S., Shimpo, S., Takeuchi, C., Wada, T., Watanabe, A., Yamada, M., Yasuda, M., and Tabata, S. (1996) Res 3: 109–136.

    CAS  Google Scholar 

  • Kawaguchi, S., Muller, J.P., Linde, D., Kuramitsu, S., Shibata, T., Inoue, Y., Vassylyev, D.G., and Yokoyama, S. (2001) EMBO J 20: 562–569.

    Article  PubMed  CAS  Google Scholar 

  • Kiesau, P., Eikmanns, U., Gutowski-Eckel, Z., Weber, S., Hammelmann, M., and Entian, K.D. (1997) J Bacteriol 179: 1475–1481.

    PubMed  CAS  Google Scholar 

  • Kontinen, V.P., Saris, P., and Sarvas, M. (1991) Mol Microbiol 5: 1273–1283.

    Article  PubMed  CAS  Google Scholar 

  • Kontinen, V.P., and Sarvas, M. (1993) Mol Microbiol 8: 727–737.

    Article  PubMed  CAS  Google Scholar 

  • Kuipers, O.P., Buist, G., and Kok, J. (2000) Res Microbiol 151: 815–822.

    Article  PubMed  CAS  Google Scholar 

  • Kunst, F., Ogasawara, N., Moszer, I., Albertini, A.M., Alloni, G., Azevedo, V., Bertero, M.G., Bessieres, P., et al (1997) Nature 390: 249–256.

    Article  PubMed  CAS  Google Scholar 

  • Lory, S. (1994) In: von Heijne, G. (ed.) Signal peptidases. R.G. Landes Company, Austin, TX, 17–29.

    Google Scholar 

  • Luirink, J., ten Hagen-Jongman, C.M., van der Weijden, C.C., Oudega, B., High, S., Dobberstein, B., and Kusters, R. (1994) EMBO J 13: 2289–2296.

    PubMed  CAS  Google Scholar 

  • Luirink, J., Samuelsson, T., and de Gier, J.-W. (2001) FEBS Lett 501:1–5.

    Article  PubMed  CAS  Google Scholar 

  • Lyon, R.L., Gibson, C.M., and Caparon, M.G. (1998) EMBO J 17: 6263–6275.

    Article  PubMed  CAS  Google Scholar 

  • Matsuyama, S., Fujita, Y., and Mizushima, S. (1993) EMBO J 12: 265–270.

    PubMed  CAS  Google Scholar 

  • Meijer, W.J., de Jong, A., Wisman, G.B.A., Tjalsma, H., Venema, G., Bron, S., and van Dijl, J.M. (1995) Mol Microbiol 17: 621–631.

    Article  PubMed  CAS  Google Scholar 

  • Meima, R., Eschevins, C., Fillinger, S., Bolhuis, A., Hamoen, L.W., Dorenbos, R., Quax, W.J., van Dijl, J.M., Provvedi, R., Chen, I., Dubnau, D., and Bron, S. (2001) J Biol Chem 277:6994–7001.

    Article  PubMed  CAS  Google Scholar 

  • Moore, M., Harrison, M.S., Peterson, E.C., and Henry, R. (2000) J Biol Chem 275: 1529–1532.

    Article  PubMed  CAS  Google Scholar 

  • Müller, J.P., Ozegowski, J., Vettermann, S., Swaving, J., van Wely, K.H.M., and Driessen, A.J.M. (2000) Biochem J 348: 367–373.

    Article  PubMed  Google Scholar 

  • Müller, J.P., Bron, S., Venema, G., and van Dijl, J.M. (2000a) Microbiol 146: 77–88.

    Google Scholar 

  • Müller, M., Koch, H.G., Beck, K., and Schäfer, U. (2000b) Progr Nucl Acid Res Mol Biol 66:107–158.

    Article  Google Scholar 

  • Nakamura, K., Takamatsu, H., Akiyama, Y., Ito, K., and Yamane, K. (1990) FEBS Lett 273: 75–78.

    Article  PubMed  CAS  Google Scholar 

  • Nakamura, K., Imai, Y., Nakamura, A., and Yamane, K. (1992a) J Bacteriol 174: 2185–2192.

    PubMed  CAS  Google Scholar 

  • Nakamura, K., Minemura, M., Nishiguchi, M., Honda, K., Nakamura, A., and Yamane, K. (1992b) Nucl Acids Res 20: 5227–5228.

    Article  PubMed  CAS  Google Scholar 

  • Nakamura, K., Yahagi, S., Yamazaki, T., and Yamane, K. (1999) J Biol Chem 274: 13569–13576.

    Article  PubMed  CAS  Google Scholar 

  • Nielsen, H., Engelbrecht, J., Brunak, S., and von Heijne, G. (1997) Protein Eng 10: 1–6.

    Article  PubMed  CAS  Google Scholar 

  • Nishiguchi, M., Honda, K., Amikura, R., Nakamura, K., and Yamane, K. (1994) J Bacteriol 176:157–165.

    PubMed  CAS  Google Scholar 

  • Novak, P., and Dev, I.K. (1988) J Bacteriol 177: 5067–5075.

    Google Scholar 

  • Ohta, T., Honda, K., Kuroda, M., Saito, K., and Hayashi, H. (1993) Biochem Biophys Res Commun 193: 730–737.

    Article  PubMed  CAS  Google Scholar 

  • Ohta, T., Saito, K., Kuroda, M., Honda, K., Hirata, H., and Hayashi, H. (1994) J Bacteriol 176:4779–4783.

    PubMed  CAS  Google Scholar 

  • Paik, S.H., Chakicherla, A., and Hansen, J.N. (1998) J Biol Chem 273: 23134–23142.

    Article  PubMed  CAS  Google Scholar 

  • Petit-Glatron, M.-F., Monteil, I., Benyahia, F., and Chambert, R. (1990) Mol Microbiol 4: 2063–2070.

    Article  PubMed  CAS  Google Scholar 

  • Petit-Glatron, M.-F., Grajcar, L., Munz, A., and Chambert, R. (1993) Mol Microbio 19: 1097–1106.

    Article  Google Scholar 

  • Piggot, P.J, and Losick, R. (2001) In: A. L. Sonenshein, J. A. Hoch, and R. Losick (eds.), Bacillus subtilis and its closest relatives: from genes to cells. American Society for Microbiology, Washington, D.C. 483–517.

    Google Scholar 

  • Power, S.D., Adams, R.M., and Wells, J.A. (1986) Proc Natl Acad Sci USA 83: 3096–3100.

    Article  PubMed  CAS  Google Scholar 

  • Pragai, Z., Tjalsma, H., Bolhuis, A., van Dijl, J.M., Venema, G., and Bron, S. (1997) Microbiol 143: 1327–1333.

    Article  CAS  Google Scholar 

  • Priest, F.G. (1977) Bacteriol Rev 41: 711–753.

    PubMed  CAS  Google Scholar 

  • Raina, S., and Missiakas, D. (1997) Annu Rev Microbiol 51: 179–202.

    Article  PubMed  CAS  Google Scholar 

  • Read, T.D., Brunham, R.C., Shen, C., Gill, S.R., Heidelberg, J.F., White, O., Hickey, E.K., Peterson, J., Utterback, T., Berry, K., Bass, S., Linher, K., Weidman, J., Khouri, H., Craven, B., Bowman, C., Dodson, R., Gwinn, M., Nelson, W., DeBoy, R., Kolonay, J., McClarty, G., Salzberg, S.L., Eisen, J., and Fraser, C.M. (2000) Nucleic Acids Res 28:1397–1406.

    Article  PubMed  CAS  Google Scholar 

  • Sadaie, Y., Takamatsu, H., Nakamura, K., and Yamane, K. (1991) Gene 98: 101–105.

    Article  PubMed  CAS  Google Scholar 

  • Samuelson, J.C., Chen, M., Jiang, F., Moller, I., Wiedmann, M., Kuhn, A., Phillips, G.J., and Dalbey, R.E. (2000) Nature 406:637–641.

    Article  PubMed  CAS  Google Scholar 

  • Santini C.-L., Bernadac, A., Zhang, M., Chanal, A., Ize, B., Blanco, C., Wu, L.-F. (2001) J Biol Chem 276: 8159–8164.

    Article  PubMed  CAS  Google Scholar 

  • Scotti, P.A., Urbanus, M.L., Brunner, J., de Gier, J.-W.L., von Heijne, G., van der Does, C., Driessen, A.J.M., Oudega, B., and Luirink, J. (2000) EMBO J 19: 542–549.

    Article  PubMed  CAS  Google Scholar 

  • Segarra, R.A., and Iandolo, J.J. (1997) Genbank, acc.nr. AAB54024.

    Google Scholar 

  • Sonenshein, A.L., Hoch, J.A., and Losick, R. (2001) In: A. L. Sonenshein, J. A. Hoch, and R. Losick (eds.), Bacillus subtilis and its closest relatives: from genes to cells. American Society for Microbiology, Washington, D.C., 3–5.

    Google Scholar 

  • Spizizen, J. (1958) Proc Natl Acad Sci USA 44: 1072–1078.

    Article  PubMed  CAS  Google Scholar 

  • Stephenson, K., Carter, N.M., Harwood, C.R., Petit-Glatron, M.-F., and Chambert, R. (1998) FEBS Lett 430: 385–389.

    Article  PubMed  CAS  Google Scholar 

  • Stöver, A.G., and Driks, A. (1999a) J Bacteriol 181: 1664–1672.

    PubMed  Google Scholar 

  • Stöver, A.G., and Driks, A. (1999b) J Bacteriol 181: 5476–5481.

    PubMed  Google Scholar 

  • Stöver, A.G., and Driks, A. (1999c) J Bacteriol 181: 7065–7069.

    PubMed  Google Scholar 

  • Suh, J.W., Boylan, S.A., Thomas, S.M., Dolan, K.M., Oliver, D.B., and Price, C.W. (1990) Mol Microbiol 4: 305–314.

    Article  PubMed  CAS  Google Scholar 

  • Sundberg, E., Slagter, J.G., Fridborg, L., Cleary, S.P., Robinson, C., and Coupland, G. (1997) Plant Cell 9: 717–730.

    PubMed  CAS  Google Scholar 

  • Thomas, J.D., Daniel, R.A., Errington, J., Robinson, C. (2001) Mol Microbiol 39: 47–53.

    Article  PubMed  CAS  Google Scholar 

  • Tjalsma, H., Noback, M.A., Bron, S., Venema, G., Yamane, K., and van Dijl, J.M. (1997) J Biol Chem 272: 25983–25992.

    Article  PubMed  CAS  Google Scholar 

  • Tjalsma, H., Bolhuis, A., van Roosmalen, M.L., Wiegert, T., Schumann, W., Broekhuizen, C.P., Quax, W.J., Venema, G., Bron, S., and van Dijl, J.M. (1998) Genes Dev 12: 2318–2331.

    Article  PubMed  CAS  Google Scholar 

  • Tjalsma, H., Kontinen, V.P., Prágai, Z., Wu, H., Meima, R., Venema, G., Bron, S., Sarvas, M., and van Dijl, J.M. (1999) J Biol Chem 274: 1698–1707.

    Article  PubMed  CAS  Google Scholar 

  • Tjalsma, H., Bolhuis, A., Jongbloed, J.D.H., Bron, S., and van Dijl, J.M. (2000) Microbiol Mol Biol Rev 64: 515–547.

    Article  PubMed  CAS  Google Scholar 

  • Tjalsma, H., Zanen, G., Bron, S., and van Dijl, J.M. (2001) In: R.E. Dalbey, and D.S. Sigman (eds.), The Enzymes: Co-and posttranslational proteolysis of proteins, 3rd edition, Volume XXII. Academic Press, San Diego, CA, USA. 3–26.

    Google Scholar 

  • van Dijl J.M., de Jong, A., Vehmaanperä, J., Venema, G., and Bron, S. (1992) EMBO J 11: 2819–2828.

    PubMed  Google Scholar 

  • van Dijl, J.M., Bolhuis, A., Tjalsma, H., Jongbloed, J.D.H., de Jong, A., and Bron, S. (2001) In: A. L. Sonenshein, J. A. Hoch, and R. Losick (eds.), Bacillus subtilis and its closest relatives: from genes to cells. American Society for Microbiology, Washington, D.C., 337–355.

    Google Scholar 

  • van Roosmalen, M.L., Jongbloed, J.D.H., Dubois, J.-Y. F., Venema, G., Bron S., and van Dijl, J.M. (2001) J Biol Chem 276: 25230–25235

    Article  PubMed  Google Scholar 

  • van Wely, K.H.M., Swaving, J., Broekhuizen, C.P., Rose, M., Quax, W.J., and Driessen, A.J.M. (1999) J Bacteriol 181: 1786–1792.

    PubMed  Google Scholar 

  • van Wely, K.H.M., Swaving, J., Freudl, R., and Driessen, A.J.M. (2001) FEMS Microbiol Rev 25: 437–454.

    Article  PubMed  Google Scholar 

  • Vasantha, N., Thompson, L.D., Rhodes, C., Banner, C., Nagle, J., and Filpula, D. (1984) J Bacteriol 159: 811–819.

    PubMed  CAS  Google Scholar 

  • Veltman, O.R., Vriend, G., van den Burg, B., Hardy, F., Venema, G., and Eijsink, V.G. (1997) FEBS Lett 405: 241–244.

    Article  PubMed  CAS  Google Scholar 

  • Wandersman, C. (1989) Mol Microbiol 3:1825–1831.

    Article  PubMed  CAS  Google Scholar 

  • Weichenrieder, O., Wild, K., Strub, K., and Cusack, S. (2000) Nature 408: 167–173.

    Article  PubMed  CAS  Google Scholar 

  • White, O., Eisen, J.A., Heidelberg, J.F., Hickey, E.K., Peterson, J.D., Dodson, R.J., Haft, D.H., Gwinn, M.L., et al (1999) Science 286: 1571–1577.

    Article  PubMed  CAS  Google Scholar 

  • Wu, S.C., Ye, R., Wu, X.C., Ng, S.C., and Wong, S.L. (1998) J Bacteriol 180: 2830–2835.

    PubMed  CAS  Google Scholar 

  • Wu, L.-F., Ize, B., Chanal, A., Quentin, Y., and Fichant, G. (2000) J Mol Microbiol Biotechno 12: 170–189.

    Google Scholar 

  • Zheng, G., Yan, L.Z., Vederas, J.C., and Zuber, P. (1999) J Bacteriol 181: 7346–7355.

    PubMed  CAS  Google Scholar 

  • Zhu, X.L., Ohta, Y., Jordan, F., and Inouye, M. (1989) Nature 339: 483–484.

    Article  PubMed  CAS  Google Scholar 

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  1. Rob Meima

    Present address: DSM Food Specialties, Wateringseweg 1, Postbus 1, 2600 MA, Delft, NL

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  1. Department of Molecular Microbiology, Vrije Universiteit, de Boelelaan 1087, 1081 HV, Amsterdam, NL

    Rob Meima

  2. Department of Pharmaceutical Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, NL

    Jan Maarten van Dijl

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    Bauke Oudega

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Meima, R., van Dijl, J.M. (2003). Protein Secretion in Gram-Positive Bacteria. In: Oudega, B. (eds) Protein Secretion Pathways in Bacteria. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0095-6_14

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  • DOI: https://doi.org/10.1007/978-94-010-0095-6_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3974-1

  • Online ISBN: 978-94-010-0095-6

  • eBook Packages: Springer Book Archive

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