Abstract
Blood coagulation is brought about by a series of proenzyme — enzyme conversions. Except thrombin, the enzyme that converts fibrinogen into fibrin, the enzymes all serve to activate a specific proenzyme. The reaction sequence is therefore properly called a cascade (1) and has interesting amplifying properties (2).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Macfarlane, R.G. An enzyme cascade in blood coagulation. Nature 202 (1964) 498–499
Hemker, H.C., P.W. Hemker. The kinetics of enzyme cascades. Proc. Roy.Soc. B. 173 (1969) 411–420
Hemker,H.C., H.L.L. Frank. Paratopic interaction, a mechanism in the generation of structure bound enzymatic activity. Experientia 33 (1977) 851–852
Nossel, H.L. (1969) The contact phase of blood coagulation. In Recent Advances in Blood Coagulation. Ed. L.Poller. Churchill, London, 60
Bangham, A.D.A. A correlation between surface charge and coagulant action of phospholipids. Nature 192 (1961) 1197–1198
Suttie, J.W., C.M. Jackson. Prothrombin structure, activation and biosynthesis. Physiol.Rev. 57 (1977) 1–70
Guillin, M.C., A. Bezeaud, D. Ménaché. The mechanism of activation of human prothrombin by an activator isolated from dispholidus typus venom. Biochim.Biophys.Acta 537 (1978) 160–168
Papahadjopoulos, D., C. Hougie, D.J. Hanahan. Influence of surface charge of phospholipids on their clot-promoting activity. Proc.Soc. Exptl.Biol.Med. 111 (1962) 412–416
Papahadjopoulos, D., D.J. Hanahan. Observations on the interaction of phospholipids and certain clotting factors in prothrombin activator formation. Biochim.Biophys.Acta 90 (1964) 436–439
Hemker,H.C., M.J.P. Kahn, P.P. Devilee. The adsorption of coagulation factors onto phospholipids; its role in the reaction mechanism of blood coagulation. Thrombos.Diathes.haemorrh. 24 (1970) 214–223
Jobin, F., M.P. Esnouf. Studies on the formation of the prothrombin converting complex. Biochem.J. 102 (1967) 666–674
Hemker, H.C., M.P. Esnouf, P.W. Hemker, A.C.W. Swart, R.G. Marfarlane. Kinetics of the formation of prothrombin converting activity in a purified system. Nature 215 (1967) 248–251
Barton, P.G., C.M. Jackson, D.J. Hanahan. Relationship between factor V and activated factor X in the generation of prothrombinase. Nature 214 (1967) 923–924
Rosing, J., G.Tans, J.W.P.Govers-Riemslag, R.F.A.Zwaal, H.C.Hemker The role of phospholipids and factor Va in the prothrombinase complex. Submitted for publication.
Cuypers, P.A., W.Th. Hermens, H.C. Hemker. Ellipsometry as a tool to study protein films at liquid-solid interfaces. Anal.Bioch. 84 (1978) 56–67
Van Holde, K.E. Physical Biochemistry. Prentice-Hall, Int. London 1971
Edidin, M., Y. Zagyansky, T.J. Lardner. Measurement of membrane protein lateral diffusion in single cells. Science 191 (1976) 466–468
Poo, M.M., R.A. Cone. Lateral diffusion of rhodopsin in the photoreceptor membrane. Nature 247 (1974) 438–441
Smith, B.A., H.M. McConnell. Determination of molecular motion in membranes using periodic pattern photobleaching. Proc.Natl.Acad. Sci.USA 75 (1978) 2759–2763
All articles in Haemostasis 7 (1978) 61–183
I.Witt, Ed. New methods for the analysis of coagulation using chromogenic substrates. W. de Gruyter, Berlin, New York, 1979
Lindhout, M.J. Personal communication.
Bouma, B.M. Personal communication.
Hemker, H.C., B.M. Bas, A.D. Muller. Activation of a proenzyme by a stoichiometric reaction with another protein; the reaction between prothrombin and staphylocoagulase. Biochim.Biophys.Acta 379 (1975) 180–188
Barton, P., E.J.Findlay. The lipid phase separation model for prothrombin activation. In The significant platelet function tests in the evaluation of hemostatic and thrombosis tendencies. Day, H.J., M.B. Zucker and H. Holmsen, Eds. (1977) U.S. Natl.Inst.Health, Bethesda, Md. 461–470
Tans, G., H.V. Zutphen, P. Comfurius, H.C. Hemker, R.F.A. Zwaal. Lipid phase transitions and procoagulant activity. Accepted for publication in Eur.J. Biochem. 1979
Vermeer, C., J.W.P. Govers-Riemslag, B.A.M. Soute, M.J. Lindhout, J. Kop, H.C. Hemker. The role of blood clotting factor V in the conversion of prothrombin and a decarboxyprothrombin into thrombin. Biochim.Biophys.Acta 538 (1978) 521–533
Lindhout, M.J., B.H.M. Kop-Klaassen, H.C. Hemker. The effect of ycarboxyglutamate residues on the enzymatic properties of the activated blood clotting factor X. I. Activity towards synthetic substrates. Biochim.Biophys.Acta 533 (1978) 342–354.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1979 ECSC, EEC, EAEC, Brussels-Luxembourg
About this chapter
Cite this chapter
Hemker, H.C., Tans, G. (1979). The Role of Surfaces in the Mechanism of Blood Coagulation. In: Schmid-Schönbein, H., Teitel, P. (eds) Basic Aspects of Blood Trauma. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9337-2_7
Download citation
DOI: https://doi.org/10.1007/978-94-009-9337-2_7
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-247-2279-2
Online ISBN: 978-94-009-9337-2
eBook Packages: Springer Book Archive