Abstract
The destruction of red blood cells (RBC’s) is regularly observed during extracorporeal circulation with heart-lung-machines and haemodialysers (1). Even in some patients with artificial heart valves the life time of RBCs was unusually shortened (5). It was often suggested that in all these cases, besides the contact of the blood cells with nonphysiological surfaces, fluid mechanical effects, such as elevated shear stresses may play an important role (1). Earlier investigations on the effect of laminar shear stress on haemolysis were often carried out in rotational viscometer-like systems (8); they clearly demonstrated that shear stress in the order of 100–200 N/m2, applied to the cells for some minutes, caused erythrocytes to lyse. In a recent study, Th. Fischer was able to visualize, that RBC’s under these conditions disintegrate into small spherical droplets (3).
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© 1979 ECSC, EEC, EAEC, Brussels-Luxembourg
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Lambert, J. (1979). Mechanical Red Cell Disruption. In: Schmid-Schönbein, H., Teitel, P. (eds) Basic Aspects of Blood Trauma. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-9337-2_14
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DOI: https://doi.org/10.1007/978-94-009-9337-2_14
Publisher Name: Springer, Dordrecht
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