Models of Prostate, Breast, Lung, and Intestinal Carcinomas Which Metastasize in Rats

Abstract

The optimal model tumor system should manifest the following characteristics: the tumor should simulate the human counterpart disease. It should be organ-related, autochthonous, and malignant. The tumor cells should multiply non-synchronously, have multiple karyotypes, and metastasize spontaneously from extravascular sites. Control animals should not develop other tumors spontaneously in the course of experimental procedures. Model systems have been developed and used in this laboratory in mice with reticulum cell sarcoma (SJL/J strain), lymphatic leukemia (AKR strain), mammary adenocarcinoma (C3H strain), and lupus-like disease in Haas strain mice (Pollard & Sharon, 1970, Pollard, et al, 1976b). Model systems do not usually comply with all of the above characteristics. In the present report, model adenocarcinomas (CAs) of prostate, lung, breast, and intestine are described in germfree (GF) and in conventional rats (Table I).