Abstract
Before the introduction of the central nervous system (CNS) prophylaxis in acute lymphoblastic leucaemia (ALL) in childhood the incidence of meningeal leucaemia was about 50%. Now it is only 10%, but extension to the meninges might become more frequent in the near future, due to a better patient survival Simultaneous the incidence of meningeal metastases from certain types of malignant lymphoma, such as mediastinal T-cell lymphoma in children and young adults and in hystiocytic lymphoma stage IV, is increasing. Breast cancer, lung cancer and melanoma are the solid tumors which may cause meningeal involvement. The symptoms have been described in the previous paper by Swen. It is the purpose of our paper to discuss the treatment of meningeal metastases and specially the role of the ventriculostomy system (V.S.) of Ommaya (O.S.). Finally the pharmacology and toxicity of MTX will be considered.
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© 1980 Martinus Nijhoff Publishers bv, The Hague
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Somers, R., Goedhart, Z.D., Ongerboer de Visser, B.W. (1980). Treatment of Meningeal Leucaemia, Meningeal Lymphoma and Carcinomatosis. In: Ongerboer de Visser, B.W., Bosch, D.A., van Woerkom-Eykenboom, W.M.H. (eds) Neuro-Oncology. Developments in Oncology, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8919-1_21
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DOI: https://doi.org/10.1007/978-94-009-8919-1_21
Publisher Name: Springer, Dordrecht
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