Abstract
International data show marked geographic variability in mortality from coronary heart disease (CHD)[1]. Mortality in the United States is among the highest and that in Japan is among the lowest reported. The determination of reasons for these marked differences is made difficult by confounding genetic, environmental, and cultural variation and by the differences in diagnostic techniques and reporting practices used in various countries. One of the methods that has been found useful in overcoming some of these difficulties is the study of migrant populations [2]. Large numbers of Japanese migrated to Hawaii and California late in the 19th century and early in the 20th century. Gordon reported a gradient of CHD mortality with men of Japanese ancestry living in the United States experiencing risks that were intermediate between the low levels in Japan and the high levels among Caucasian Americans [3,4]. Gordon also demonstrated a gradient of increasing CHD mortality among Japanese men in Japan, Hawaii, and California. The gradient of mortality from cerebrovascular disease was the reverse.
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Kagan, A., Marmot, M.G., Kato, H. (1980). The Ni-Hon-San Study of Cardiovascular Disease Epidemiology. In: Kesteloot, H., Joossens, J.V. (eds) Epidemiology of Arterial Blood Pressure. Developments in Cardiovascular Medicine, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8893-4_26
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DOI: https://doi.org/10.1007/978-94-009-8893-4_26
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