Skip to main content

Inhibin: New Gonadal Hormone

  • Chapter

Part of the book series: Clinics in Andrology ((CLAN,volume 5))

Abstract

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are secreted independently of each other under various physiologic and pathologic conditions (Franchimont and Burger, 1975). Thus, at the onset of the follicular phase of the menstrual cycle, FSH levels are elevated and progressively decrease, while those of LH are very low at the beginning of the cycle but increase gradually as the follicle develops. During the premenopausal period, FSH levels increase markedly without any change in LH (Korenman and Sherman, 1976). Once the menopause has occurred, FSH levels are clearly higher than those found during the menstrual cycle. In contrast, LH levels, while also being increased, rarely reach concentrations higher than those seen during the ovulatory peak in the menstrual cycle.

Article Note

Supported by grant 74.039, World Health Organization, Geneva.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Baker HWG, Bremner WJ, Burger HG, De Kretser DM, Dulmanis A, Eddie LW, Hudson B, Keogh EJ, Lee VWK, Rennie GC (1976) Testicular control of follicle stimulating hormone secretion. Recent Prog Horm Res 32: 429.

    PubMed  CAS  Google Scholar 

  • Baker HWG, Burger HG, De Kretser DM, Eddie LW, Higginson RE, Hudson B, Lee VWK (1978) An in vitro bioassay for monitoring purification of inhibin from ovine testicular secretions. Int J Androl 2 [Suppl]: 115.

    Article  CAS  Google Scholar 

  • Blanc MR, Cahoreau C, Courot M, Dacheux JL, Hochereau DE-Reviers MTh, Pisselet CI (1978) Plasma follicle stimulating hormone (FSH) and luteinizing hormone (LH) suppres-sion in the cryptorchid ram by a non-steroid factor (inhibin) from ram rete testis fluid. Int J Androl 2 [Suppl]: 139.

    Article  CAS  Google Scholar 

  • Cahoreau C, Blanc MR, Dacheux JL, Pisselet CI, Courot M (1979) Inhibin activity in ram rete testis fluid; depression of plasma follitropin (FSH) and lutropin (LH) in the castrate and cryptorchid ram. J Reprod Fertil (in press).

    Google Scholar 

  • Channing CP, Anderson LD, Hodgen GD (1979) Inhibitory effect of charcoal treated porcine follicular fluid upon serum FSH levels and follicular development in the rhesus monkey. In: Channing CP, Marsh J, Sadler W (eds) Proceedings of the workshop on ovarian follicular and corpus luteum function, ( 1978 ). New York: Plenum, p 407.

    Google Scholar 

  • Chappel SC, Acott T, Spies HG (1979) Inhibition of in vivo and in vitro follicle-stimulating hormone secretion by steroid-free ovarian extracts. In:Channing CP, Marsh J, Sadler W (eds) Proceedings of the workshop on ovarian follicular and corpus luteum function, 1978. New York: Plenum, p 361.

    Google Scholar 

  • Chari S, Duraiswami S, Franchimont P (1978) Isolation and characterization of inhibin from bull seminal plasma. Acta Endocrinol (Kbh) 87: 434.

    CAS  Google Scholar 

  • Chari S, Hopkinson CRN, Daume E, Sturm G (1979) Purification of inhibin from human ovarian follicular fluid. Acta Endocrinol (Kbh) 90: 157.

    CAS  Google Scholar 

  • Davies RV, Main SH, Setchell BP (1978) Inhibin evidence for its existence, methods of bioassay and nature of the active material. Int J Androl 2 [Suppl]: 102.

    Article  CAS  Google Scholar 

  • De Jong FH, Sharpe RM (1976) Evidence for inhibin-like activity in bovine follicular fluid. Nature 263: 71.

    Article  PubMed  Google Scholar 

  • De Jong FH, Welschen R. Hermans WP. Smith SD. Van Der Molen HJ (1978) Effects of testicular and ovarian inhibin-like activity, using in vitro and in vivo systems. Int J Androl 2 [Suppl]: 125.

    Article  Google Scholar 

  • De Kretser DM, Burger HG, Fortune D, Hudson B, Long AR, Paulsen CA, Taft HP (1972) Hormonal, histological and chromosomal studies in adult males with testicular disorders. J Clin Endocrinol Metab 35: 392.

    Article  PubMed  Google Scholar 

  • Demoulin A, Koulischer L, Hustin J, Hazee-Hagelstein MT, Lambotte R, Francimont P (1979) Organ culture of mammalian testis. III. Inhibin secretion. Horm Res 10: 177.

    Article  PubMed  CAS  Google Scholar 

  • Erickson GF, Hsueh AJW (1978) Secretion of ‘inhibin’ by rat granulosa cells in vitro Encocrinology 193: 1960.

    Google Scholar 

  • Franchimont P (1972) Human gonadotrophin secretion. J. Coll Physicians London 6: 283.

    CAS  Google Scholar 

  • Franchimont P (1976) Etude des mécanismes de régulation de la sécrétion spécifique de FSH et de LH. In: Colloque de synthèse de l’NSERIM (Paris), Action thématique 22 et 35: neuroendocrinologie, p 253.

    Google Scholar 

  • Franchimont P, Burger HG (1975) Human growth hormone and gonadotrophins in health and disease. Amsterdam, New York: North-Holland, American Elsevier.

    Google Scholar 

  • Franchimont P, Millet D, Vendrely E, Letawe J, Legros J J, Netter A (1972) Relationship between spermatogenesis and serum gonadotropin levels in azoospermias and oligospermia. J Clin Endocrinol Metab 34: 1003.

    Article  PubMed  CAS  Google Scholar 

  • Franchimont P, Demoulin A, Bourguignon JP (1975a) Clinical use of LH-RH test as a diagnostic tool. Horm Res 6: 177.

    Article  PubMed  CAS  Google Scholar 

  • Franchimont P, Chari S, Demoulin A (1975b) Hypothalamus-pituitary-testis interaction. J Reprod Fertil 44: 335.

    Article  CAS  Google Scholar 

  • Franchimont P, Chari S, Hagelstein MT, Duraiswami S (1975c) Existence of a follicle stimulating hormone inhibiting factor inhibin in bull seminal plasma. Nature 257: 402.

    Article  CAS  Google Scholar 

  • Franchimont P. Chari S, Hazee-Hagelstein MT, Debruche ML, Duraiswami S (1977) Evidence for the existence of inhibin. In: Troen Ph, Nankin HR (eds) The testis in normal and infertile men. New York: Raven, p 253.

    Google Scholar 

  • Franchimont P, Demoulin A, Verstraelen-Proyard J, Hazee- Hagelstein MT, Walton JS, Waites GMH (1978) Nature and mechanisms of action of inhibin: perspective in regulation of male ferility. Int J Androl 2 [Suppl]: 69.

    Article  CAS  Google Scholar 

  • Hopkinson CRH, Sturm G, Daume A, Fritze E, Hirschhauser C (1975) Non-steroidal inhibition of FSH secretion by bovine ovarian fluid in male and female rats. IRCS 3: 588.

    CAS  Google Scholar 

  • Hopkinson CRH, Daume E, Sturm G, Fritze E, Kaiser S, Hirschhauser C (1977) Inhibin-like activity of bovine ovarian extracts in male and female rats. J Reprod Fertil 50: 93.

    Article  PubMed  CAS  Google Scholar 

  • Keogh EJ, Lee VWK, Rennie GC, Burger HG, Hudson B, De Kretser DM (1976) Selective suppression of FSH by testicular extracts. Endocrinology 98: 997.

    Article  PubMed  CAS  Google Scholar 

  • Korenman SG, Sherman BM (1976) Hormonal regulation in normal and abnormal menstrual cycle. In: James VHT, Serio M, Giusti G (eds) The endocrine function of the human ovary. Vol 7. London, New York: Academic p 359.

    Google Scholar 

  • Lee VWK, Keogh EH, De Kretser DM, Hudson B (1974) Selective suppression of FSH by testis extracts. IRCS 2: 1406.

    CAS  Google Scholar 

  • Lorenzen JR, Channing CP, Schwartz HB (1978) Partial characterization of FSH suppressing activity (folliculostatin) in porcine follicular fluid using the metestrous rat as an in vivo bioassay model Biol Reprod 19: 635.

    Article  PubMed  CAS  Google Scholar 

  • Lugaro G, Cassellato MM, Mazzola G, Fachini G, Carrea B (1974) Evidence for the existence in spermatozoa of a factor inhibiting hormone synthesis. Neuroendocrinology 15: 62.

    Article  PubMed  CAS  Google Scholar 

  • Marder ML, Channing CP, Schwartz NB (1977) Suppression of serum follicle stimulating hormone in intact and acutely ovariectomized rats by porcine follicular fluid. Endocrinology 101: 1639.

    Article  CAS  Google Scholar 

  • McCullagh DD (1932) Dual endocrine activity of the testis. Science 76: 19.

    Article  PubMed  CAS  Google Scholar 

  • Moodbidri SB, Joshi LR, Sheth AR (1976) Isolation of an inhibin-like substance from ram testis. IRCS 4: 217.

    CAS  Google Scholar 

  • Nandini SG, Lidner H, Mougdal NR (1976) A model system for studying inhibin. Endocrinology 98: 1460.

    Article  PubMed  CAS  Google Scholar 

  • Pasteels JL, Sheridan R, Gaspar S, Franchimont P (1977) Synthesis and release of gonadotrophins and their subunits by long term organ cultures of human foetal hypophyses. Mol Cell Endocrinol 9: 1.

    Article  PubMed  CAS  Google Scholar 

  • Paulsen CA, Leonard M, De Kretser DM, Leach RB (1972) Interrelationship between spermatogenesis and follicle stimu-lating hormone levels. In: Saxena BB, Beling CG, Gandy HM (eds) Gonadotropins. New York: Wiley Intersciences, p 628.

    Google Scholar 

  • Sairam MR, Ranganatham MR, Lamothe P (1978) Purification and characterization of a follitropin suppressing principle from bull ejaculate. In: Program of the 11th annual meeting of society for the study of reproduction, p 53.

    Google Scholar 

  • Schally AV, Arimura A, Kastin AJ, Matsuo H, Baba Y, Redding TW, Nair RMG, Debeljuk L (1971) Gonadotrophin releasing hormone: one polypeptide regulated secretion of luteinizing and follicle stimulating hormone. Science 173: 1036.

    Article  PubMed  CAS  Google Scholar 

  • Setchell BP, Sirinathsinghji DJ (1972) Antigonadotropic activity in rete testis fluid, a possible inhibin. J Endocrinol 53: LX.

    PubMed  CAS  Google Scholar 

  • Setchell BP, Jacks F (1974) Inhibin-like activity in rete testis fluid. J Endocrinol 62: 675.

    Article  PubMed  CAS  Google Scholar 

  • Setchell BP, Main SJ (1974) Bibliography (with review) on inhibin. Bibliogr Reprod 24: 245, 361.

    Google Scholar 

  • Setchell BP, Davies RV, Main SJ (1977) Inhibin. In: The testis, Vol 6, p 189.

    Google Scholar 

  • Steinberger E (1971) Hormonal control of mammalian spermatogenesis. Physiol Rev 52: 1.

    Google Scholar 

  • Steinberger A, Steinberger E (1976) Secretion of an FSH-inhibiting factor by cultured Sertoli cells. Endocrinology 99: 918.

    Article  PubMed  CAS  Google Scholar 

  • Steinberger A, Steinberger E (1977) Inhibition of FSH by a Sertoli factor in vitro. In: Troen Ph, Nankin HR (eds) The testis in normal and infertile men. New York: Raven, p 271.

    Google Scholar 

  • Swerdloff RS, Walsch PC, Jacobs HS, Odell WD (1971) Serum LH and FSH during sexual maturation in the male rat: effect of castration and cryptorchidism. Endocrinology 88: 120.

    Article  PubMed  CAS  Google Scholar 

  • Tougard C, Kerdelhue B, Tixier-Vidal A, Jutisz M (1971) Localisation par cyto-immuno-enzymologie de la LH, de ses sous-unités et de la FSH dans l’adénohypophyse de la rate castrée. CR Acad Sci (Paris) 273: 897.

    CAS  Google Scholar 

  • Welschen R, Hermans WP, Dullaart J, De Jong FH (1977) Effects of an inhibin-like factor present in bovine and porcine follicular fluid on gonadotrophin levels in ovariectomized rats. J Reprod Fertil 50: 129.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1980 Martinus Nijhoff Publishers bv. The Hague/Boston/London

About this chapter

Cite this chapter

Franchimont, P., Demoulin, A., Verstraelen-Proyard, J., Hazee-Hagelstein, M.T., Bourguignon, J.P. (1980). Inhibin: New Gonadal Hormone. In: Cunningham, G.R., Schill, WB., Hafez, E.S.E. (eds) Regulation of Male Fertility. Clinics in Andrology, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8875-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-8875-0_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8877-4

  • Online ISBN: 978-94-009-8875-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics