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Antiandrogens: Basic Concepts and Clinical Trials

  • Chapter
Regulation of Male Fertility

Part of the book series: Clinics in Andrology ((CLAN,volume 5))

Abstract

Spermatogenesis and spermiogenesis are hormone- dependent processes. Consequently, hypophysectomy leads to testicular atrophy with arrest of spermatogenesis (Smith, 1930). According to the classical concept of endocrine regulation of testicular function, Leydig cell function (testicular androgen biosynthesis) is controlled by pituitary luteinizing hormone, (LH) while spermatogenesis is controlled by follicle-stimulating hormone (FSH). However, it was soon shown that LH — via stimulation of androgen synthesis — is also important for the maintenance of spermatogenesis in hypophysectomized animals: experiments have demonstrated that spermatogenesis can be maintained in hypophysectomized animals by means of adequate replacement with androgens alone or with androgen precursors, although the doses required are extremely high (e.g., in rats 0.3–1.0 mg testosterone propionate/day/animal subcutaneously).

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Authors
  1. F. Neumann
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  2. B. Schenck
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Veterans Administration Center, 2002 Holcome Blvd., Houston, TX, 77211, USA

    G. R. Cunningham

  2. Andrology Unit of the Department of Dermatology, University of Munich, D-8000, Munich 2, Frauenlobstr. 9-11, West Germany

    W.-B. Schill

  3. Department of Gynecology-Obstetrics, Wayne State University School of Medicine, Medical Research Building, 550 E. Canfield Ave., Detroit, MI, 48201, USA

    E. S. E. Hafez

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© 1980 Martinus Nijhoff Publishers bv. The Hague/Boston/London

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Neumann, F., Schenck, B. (1980). Antiandrogens: Basic Concepts and Clinical Trials. In: Cunningham, G.R., Schill, WB., Hafez, E.S.E. (eds) Regulation of Male Fertility. Clinics in Andrology, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8875-0_10

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  • DOI: https://doi.org/10.1007/978-94-009-8875-0_10

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