Abstract
Major histocompatibility complex is a set of closely linked genes controlling cell surface antigens, immune response, and complement activity. MHC was found in every vertebrate species which was sufficiently studied and it is involved in a number of biological processes including defence against viral infections. We discuss the structure and function of the major products of the MHC and list a number of other functions of the MHC of the mouse (H-2) and of man (HLA).
It was shown in the mouse that the H-2 genotype influences to a considerable degree the outcome of the interaction between the host and the oncogenic agent (virus) or the tumor. Several examples of the influence of the H-2 complex on the susceptibility to viral oncogenesis and tumor growth are listed, and the genes responsible for this effect and the mode of their action are discussed. Similar mechanisms may also be active in man. There are several examples of association of tumor incidence with certain HLA antigens, and understanding of the role of the MHC in processes involved in oncogenesis and tumor growth may ultimately also have practical implications.
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Démant, P., Cleton, F.J. (1980). Histocompatibility Genes and Neoplasia. In: Cleton, F.J., Simons, J.W.I.M. (eds) Genetic Origins of Tumor Cells. Developments in Oncology, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8823-1_7
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DOI: https://doi.org/10.1007/978-94-009-8823-1_7
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