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Adrenocorticosteroid Hormones

  • Chapter
Brain Metastasis

Part of the book series: Metastasis: A Monograph Series ((METS,volume 2))

Abstract

The single most dramatic advance in the treatment of brain metastasis has been the introduction of adrenal glucocorticoids. These drugs, first used to treat brain metastasis by Kofman and his colleagues (1957), have revolutionized the initial treatment of metastatic brain tumor and have at times restored moribund patients to full neurologic function, often within hours. Although glucocorticoids are now used to treat several brain disorders, in no other illness is the response so consistent and so dramatic as in treating brain metastases (Fishman 1975; Reulen 1976). This chapter reviews the effects of glucocorticoids, both salutary and untoward, on patients with brain metastases and discusses the mechanism(s) by which these agents exert their beneficial effect.

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Authors
  1. Joel R. L. Ehrenkranz
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  2. Jerome B. Posner
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Editors and Affiliations

  1. Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, New York, USA

    Leonard Weiss Sc.D., M.D., Ph.D.

  2. Department of Radiation Therapy, Southern California Permanente Medical Group, Los Angeles, California, USA

    Harvey A. Gilbert M.D.

  3. Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Jerome B. Posner M.D.

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Ehrenkranz, J.R.L., Posner, J.B. (1980). Adrenocorticosteroid Hormones. In: Weiss, L., Gilbert, H.A., Posner, J.B. (eds) Brain Metastasis. Metastasis: A Monograph Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8799-9_23

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