Abstract
In patients with ocular defects caused by the tuberculostaticum ETHAMBUTOL the spectral data obtained under selective chromatic adaptation with psychophysical and electrophysiological methods clearly indicate that signals of all three types of spectrally different cones are present in the visual cortex; however, the signs of color-opponent interactions between the individual cone mechanisms are lacking. Therefore it becomes evident that ETHAMBUTOL mainly affects the function of red/green antagonistic neurons. This method of investigation in patients as described here permits differentiation between toxic alterations affecting the cone receptor and their direct pathways to the visual cortex from those disturbing the action of color-antagonistic mechanisms, upon which chromatic as well as spatial coding strongly relies.
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Zrenner, E., Krüger, C.J. (1981). Ethambutol Mainly Affects the Function of Red/Green Opponent Neurons. In: Spekreijse, H., Apkarian, P.A. (eds) Visual Pathways. Documenta Ophthalmologica Proceedings Series, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8656-5_2
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