Abstract
Migration of sensitised lymphocytes in swine was studied by measuring the lymphocyte proliferative response to K88 antigen and to class specific antisera.
Oral administration of antigen (E. coli 08 : 087: K88ab) resulted in the appearance of K88 positive cells in peripheral and mammary lymph nodes In lactating sows these cells appear preferentially in mammary lymph nodes. The most effective vaccination schedule was found to be frequent vaccination over a long period.
A route of migration of lymphocytes is postulated and we conclude that oral vaccination of pregnant sows results in K88 positive cells, which — during lactation — home to the mammary lymph nodes.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bourne, F.J., 1976. Vet. Rec., 98, 499.
Dam, R.H.v., van Kooten, P.J.S. and van der Donk, J.A., 1978. J. Immunol. Meth. 21, 217.
Goldblum, R.H. et al., 1975. Nature, 257, 797.
Kortbeek-Jacobs, N. and van der Donk, H., 1978. J. Immunol. Meth. 24, 195.
Kortbeek-Jacobs, N. and van der Donk, H., manuscript in preparation. Shimizu, M. and Shimizu, Y., 1979. Infect. Immun., 23, 239.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 ECSC, EEC, EAEC, Brussels-Luxembourg
About this chapter
Cite this chapter
Kortbeek-Jacobs, N., van der Donk, H. (1981). Homing of Lymphocytes after Oral Vaccination of the Sow. In: Bourne, F.J. (eds) The Mucosal Immune System. Current Topics in Veterinary Medicine and Animal Science, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8331-1_27
Download citation
DOI: https://doi.org/10.1007/978-94-009-8331-1_27
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-8333-5
Online ISBN: 978-94-009-8331-1
eBook Packages: Springer Book Archive