Abstract
Preruminant calves given a series of feeds of heated soyabean flour (HSF) quickly developed high titres of IgG antibodies in the serum specific for the soyabean proteins glycinin and B-conglycinin, reaginic antibodies were also detected. After sensitisation by feeding with HSF, ingestion of soluble soyabean proteins caused, in a majority of animals, gross abnormalities in gastrointestinal function. The rate of flow of digesta through the small intestine was greatly increased and there was a dramatic, but transitory, rise in the permeability of the intestinal mucosa to protein molecules. Mucosal integrity was assessed by infusing into the abomasum either milk alone or milk mixed with soyabean proteins and quantitating the leakage of β-lactoglobulin into the blood. In sensitised calves intestinal permeability changed 1–2 h after ingestion of soyabean protein, was greatly elevated at 4–6h and had almost returned to normal again by 24 h.
A progressive increase in the sensitivity of the intestine to soyabean antigens was accompanied by a rise in the titre of homologous serum antibodies.
Feeding calves with ovalbumin also led to high antibody levels and similar gastrointestinal reactions.
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References
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© 1981 ECSC, EEC, EAEC, Brussels-Luxembourg
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Kilshaw, P.J. (1981). Gastrointestinal Hypersensitivity in the Preruminant Calf. In: Bourne, F.J. (eds) The Mucosal Immune System. Current Topics in Veterinary Medicine and Animal Science, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8331-1_10
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DOI: https://doi.org/10.1007/978-94-009-8331-1_10
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