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Developmental Renal Physiology

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Pediatric Nephrology

Part of the book series: Developments in Nephrology ((DINE,volume 3))

Abstract

In 1940, Barnett(1) demonstrated by inulin clearance that the rates of glomerular filtration in neonates were considerably lower than levels found in older children and adults, thus launching the field of developmental renal physiology. This observation has been confirmed repeatedly. Barnett also suggested that with birth, the rate of increase in renal function that proceeds in utero is markedly accelerated, even in premature infants, permitting the kidney to assume excretory and regulatory functions in the absence of the placenta. This phenomenon has been demonstrated nicely by Guignard and associates(2), who studied low-birth-weight infants during the first 72 hours after birth and over the subsequent three weeks. The increase in GFR between the 28th and 35th week of gestation was more rapid than during the subsequent five weeks, but a striking acceleration after birth was apparent.

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Authors
  1. C. M. Edelmann Jr.
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Editors and Affiliations

  1. St. Christopher’s Hospital for Children, Philadelphia, PA, USA

    Alan B. Gruskin MD (President) (President)

  2. Section of Nephrology, Children’s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA, 19104, USA

    Michael E. Norman MD (Secretary General) (Secretary General)

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© 1981 Martinus Nijhoff Publishers, The Hague

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Edelmann, C.M. (1981). Developmental Renal Physiology. In: Gruskin, A.B., Norman, M.E. (eds) Pediatric Nephrology. Developments in Nephrology, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8319-9_2

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  • DOI: https://doi.org/10.1007/978-94-009-8319-9_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8321-2

  • Online ISBN: 978-94-009-8319-9

  • eBook Packages: Springer Book Archive

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