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Acquisition of Immunological Competence to Gastro-Intestinal Trichostrongyles by Young Ruminants: Epidemiological Significance

  • E. J. L. Soulsby
  • Gillian Monsell
  • Sheelagh Lloyd
Part of the Current Topics in Veterinary Medicine and Animal Science book series (CTVM, volume 9)

Abstract

The acquisition of immune competence varies with the species of animal and with the kind of infection or antigen presented. The neonatal lamb fails to develop a significant protective immune response to helminth infections until it is several weeks or months of age. By this time, in the field, animals may have been subjected to a severe, even fatal, challenge from the herbage. Animals unable to mount a satisfactory immune response to control infection may be a major source of infection for other animals. There appears to be a sequential development of immunological competence in the lamb to various antigens and the differences in responsiveness to antigens of helminths on the part of lambs are discussed with reference to genetic variability of animals (responders and non-responders), maternally transferred antibody, colostral transfer of tolerogenic substances, suppressive factors in newborn serum, neonatal suppressor cells and induced suppressor cell formation.

Keywords

Suppressor Cell Helminth Infection Worm Burden Intestinal Nematode Haemonchus Contortus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adams, D.B. 1978. The induction of selective immunological unresponsiveness in cells of blood and lymphoid tissue during primary infection of sheep with the abomasal nematode Haemonchus contortus. Aust. J. Exp. Biol. Med. Sci., 56, 107–118PubMedCrossRefGoogle Scholar
  2. Auerbach, R. and Clark, S. 1975. Immunological tolerance: transmission from mother to offspring. Science, 189, 811–813PubMedCrossRefGoogle Scholar
  3. Ballantyne, A.J., Sharpe, M.J. and Lee, D.L. 1978. Changes in the adenylate energy charge of Nippostrongylus brasiliensis and Nematodirus battus during the development of immunity to these nematodes in their hosts. Parisitology, 76, 211–220CrossRefGoogle Scholar
  4. Beer, A.E. and Billingham, R.E. 1978. Immunoregulatory aspects of pregnancy. Federation Proc., 37, 2374–2378Google Scholar
  5. Burrells, C., Wells, P.W. and Sutherland, A.D. 1978. Reactivity of ovine lymphocytes to phytohaemagglutinin and pokeweed mitogen during pregnancy and in the immediate post-parturient period. Clin. Exp. Immunol. 33, 410–415Google Scholar
  6. Chen, P.C. 1972. Peripheral lymphoid cell responses of sheep to gastrointestinal parasitisms. Dissertation for the PhD degree. University of PennsylvaniaGoogle Scholar
  7. Chen, P.C. and Soulsby, E.J.L. 1976., Haemonchus contortus infection in ewes. Blastogenic responses of peripheral blood leucocytes to third stage larval antigen. Int. J. Parasit., 6, 135–141CrossRefGoogle Scholar
  8. Chiejina, S.N. and Sewell, M.H.H. 1974. Experimental infections with Trichostrongylus colubriformis (Giles, 1892) Loos, 1905 in lambs: worm burden, growth rate and host resistance resulting from prolonged escalating infection. Parasitology, 69, 301–314PubMedCrossRefGoogle Scholar
  9. Cole, G.J. and Morris, B. 1973. The lymphoid apparatus of the sheep: its growth, development and significance in immunologic reactions. Adv. Vet. Sci. Comp. Med., 17, 225–263PubMedGoogle Scholar
  10. Connan, R.M. 1976. Effect of lactation on the immune response to gastrointestinal nematodes. Vet. Rec., 99 476–477Google Scholar
  11. Dineen, J.K., Gregg, P. and Lascelles, A.K. 1978. The response of lambs to vaccination at weaning with irradiated Trichostrongylus colubriforwds larvae: segregation into “responders” and “non-responders”. Int. J. Parasit. 8,59–63CrossRefGoogle Scholar
  12. Dineen, J.K. and Windon, R.G. 1980. The effect of sire selection on the response of lambs to vaccination with irradiated Trichostrongylus colubriformis larvae. Int. J. Parisit., 10, 189–196CrossRefGoogle Scholar
  13. Etlinger, H.M. and Chiller, J.M. 1979a. Maturation of the lymphoid system. I. Induction of tolerance in neonates with a T-dependent antigen that is an obligate immunogen in adults. J. Immunol., 122, 2558–2563Google Scholar
  14. Etlinger, H.M. and Chiller, J.M. 1979b. Maturation of the lymphoid system. H. Characterization of the cellular levels of unresponsiveness induced in neonates by a T-dependent antigen that is an obligate immunogen in adults. J. Immunol., 122, 2564–2570Google Scholar
  15. Fahey, K.T. and Morris, B. 1978. Humoral immune reponses in foetal sheep Immunology, 35, 651–661Google Scholar
  16. Gregg, P. and Dineen J.K. 1978. The response of sheep vaccinated with irradiated Trichostrongylus colubriformis larvae to impulse and sequential challenge with normal larvae. Vet. Parasit., 4, 49–53Google Scholar
  17. Hayward, A.R. and Lydyard, P.M. 1978. Suppression of B lymphocyte differentiation by newborn T lymphocytes with an Fc receptor for IgM. Clin. Exp. Immunol., 34, 374–378Google Scholar
  18. Husband, A.J. and Lascelles, A.K. 1975. Antibody responses to neonatal immunization in calves. Res. Vet. Sci., 18, 201–207Google Scholar
  19. Manton, V.J.A., Peacock, R., Poynter, D., Silverman, P.H. and Terry, R.J. 1962. The influence of age and naturally acquired resistance to Haemonchus contortus. Res. Vet. Sci., 3, 308–313Google Scholar
  20. Mattingly, J.M. and Waksman, B.H. 1978. Immunolgical suppression after oral administration of antigen. I. Specific suppressor cells formed in rat Peyer’s Patches after oral administration of sheep erythrocytes and their systemic migration. J. Immunol., 121, 1878–1883PubMedGoogle Scholar
  21. Mulligan, W., Gordon, H.McL., Stewart, D.F. and Wagland, B.M. 1961. The use of irradiated larvae as immunizing agents in. Haemonchus contortus and Trichostrongylus cubriformis infection in sheep. Aust. J. Agric. Res., 12, 1175–1187CrossRefGoogle Scholar
  22. Ngan, J. and Kind, L.S. 1978. Suppressor T cells for IgE and IgG in Peyer’s Patches of mice made tolerant by the oral administration of ovalbumin. J. Immunol., 120, 861–865PubMedGoogle Scholar
  23. Olding, L.B. and Oldstone, M.B.A. 1976. Thymus-derived peripheral lymphocytes from human new borns inhibit division of the mothers lymphocytes. J. Immunol., 116, 682–686PubMedGoogle Scholar
  24. Pavia, C.S. and Stites, D.P. 1979. Immunosuppressive activity of murine new born spleen cells. I. Selective inhibition ofin vitro lymphocyte activation. Cell. Immunol., 42, 48–60Google Scholar
  25. Riffkin, G.G. and Dobson, C. 1979. Predicting resistance of sheep to Haemonchus contortus infections. Vet. Parasit., 5, 365–378Google Scholar
  26. Rothwell, T.L.N., LeJambre, L.F., Adams, D.B. and Love, R.J. 1978. Trichostrongy Zus colubriformis infection of guinea pigs: genetic basis for variation in susceptibility to infection among outbred animals. Parasitology, 76, 201–209PubMedCrossRefGoogle Scholar
  27. Silverstein, A.M., Uhr, J.W., Kraner, K.L. and Lukes, R.J. 1963. Fetal response to antigens stimulus. II. Antibody production by the fetal lamb. J. Exp. Med., 117 799–812PubMedCrossRefGoogle Scholar
  28. Silverstein, A.M., Prendergast, R.A. and Kraner, K.L. 1964. Fetal response to antigenic stimulus. Pt. 4. The rejection of skin homografts by the fetal lamb. J. Exp. Med., 119, 955–964Google Scholar
  29. Soulsby, E.J.L. 1966. The mechanisms of immunity to gastro-intestinal nematodes. In: Biology of Parasites (Ed. Soulsby E.J.L.), Academic Press, New York and London, pp 255–276Google Scholar
  30. Stumberg, J.E. 1933. The detection of proteins of the nematode Haemonchus contortus in the sera of infected sheep and goats. Amer. J. Hyg., 18, 247–265Google Scholar
  31. Tomasi, T.B. Jr. 1978. Suppressive factors in amniotic fluid and new born serum: Is a-fetoprotein involved? Cell. Immunol., 37, 459–460Google Scholar
  32. Urquhart, G.M., Jarrett, W.F.H., Jennings, F.N., Maclntyre, W.I.M. and Mulligan, W. 1966. Immunity to Haemonchus contortus infection. Relationship between age and successful vaccination with irradiated larvae. Amer. J. Vet. Res., 27, 1645–1648PubMedGoogle Scholar
  33. Varela-Diaz, V. 1960. The immunological response to gastro-intestinal parasites of sheep. Dissertation for. the PhD degree. University of PennsylvaniaGoogle Scholar
  34. Varela-Diaz, V. and Soulsby, E.J.L. 1972. Immunoglobulin synthesis in sheep. Ig G2 deficiency in neonatal lambs. Res. Vet. Sci., 13, 99–100PubMedGoogle Scholar
  35. Wakelin, D. 1975. Genetic control of immune response to parasites: Immunity to Trichuris muris in inbred and random-bred strains of mice. Para-sitology, 71, 51–60Google Scholar

Copyright information

© ECSC, EEC, EAEC, Brussels-Luxembourg 1981

Authors and Affiliations

  • E. J. L. Soulsby
    • 1
  • Gillian Monsell
    • 1
  • Sheelagh Lloyd
    • 1
  1. 1.Department of Clinical Veterinary MedicineUniversity of CambridgeCambridgeUK

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