Abstract
The acquisition of immune competence varies with the species of animal and with the kind of infection or antigen presented. The neonatal lamb fails to develop a significant protective immune response to helminth infections until it is several weeks or months of age. By this time, in the field, animals may have been subjected to a severe, even fatal, challenge from the herbage. Animals unable to mount a satisfactory immune response to control infection may be a major source of infection for other animals. There appears to be a sequential development of immunological competence in the lamb to various antigens and the differences in responsiveness to antigens of helminths on the part of lambs are discussed with reference to genetic variability of animals (responders and non-responders), maternally transferred antibody, colostral transfer of tolerogenic substances, suppressive factors in newborn serum, neonatal suppressor cells and induced suppressor cell formation.
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© 1981 ECSC, EEC, EAEC, Brussels-Luxembourg
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Soulsby, E.J.L., Monsell, G., Lloyd, S. (1981). Acquisition of Immunological Competence to Gastro-Intestinal Trichostrongyles by Young Ruminants: Epidemiological Significance. In: Nansen, P., Jørgensen, R.J., Soulsby, E.J.L. (eds) Epidemiology and Control of Nematodiasis in Cattle. Current Topics in Veterinary Medicine and Animal Science, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8311-3_35
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DOI: https://doi.org/10.1007/978-94-009-8311-3_35
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