General Review on Pharmacokinetics of Antimicrobial Drugs in Relation to Respiratory Infections

  • H. Mattie
Part of the New Perspectives in Clinical Microbiology book series (NPCM, volume 4)


Even those who are only slightly familiar with pharmacokinetic concepts will know that the two-compartment open model is often used in explaining the course of plasma concentrations of a drug [1]. What is often forgotten is that this model is primarily not a biological model but a mathematical one, although the latter is compatible with some biological facts. This has led to the assumption that a biological model is the basis for the mathematical model.


Pharmacokinetic Model Biological Model Fibrin Clot Tissue Content Bronchial Mucosa 
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© Martinus Nijhoff Publishers, The Hague 1981

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  • H. Mattie

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