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Search for a Primate Model of Human Sleep-Related Hormone Secretion

  • H.-J. Quabbe
Part of the Developments in Endocrinology book series (DIEN, volume 1)

Abstract

In man, an influence of the sleep/wake cycle on the secretory pattern of certain hormones is well documented. The secretion of growth hormone (GH), prolactin (PRL) — and luteotropin (LH) during puberty — is stimulated by the occurrence of sleep, while thyrotropin (TSH) (and possibly LH during the early follicular phase in adult women) may be inhibited (1). Sleep-deprivation and sleep-reversal experiments have been used to prove that sleep itself affects hormone secretion in these cases irrespective of the time of the day. These studies have revealed that different hormones have different links to sleep. Thus, a major GH secretory episode occurs regularly during the first slow-wave-sleep (SWS) phase of nocturnal sleep and only little or no GH is secreted during the remaining sleep (2, 3, 4). In contrast, PRL secretion increases with the onset of sleep, then the plasma concentration remains elevated and highest values are often reached towards the end of sleep. TSH plasma concentrations attain highest levels in the evening before the onset of sleep, and this seems to be the result of an endogenous circadian rhythm.

Keywords

Growth Hormone Anorexia Nervosa Rhesus Monkey Sleep Deprivation Growth Hormone Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© ECSC, EEC, EAEC, Brussels-Luxembourg 1981

Authors and Affiliations

  • H.-J. Quabbe
    • 1
  1. 1.Department of Internal Medicine, Section of Endocrinology, Klinikum SteglitzFreie Universität BerlinBerlin 45Germany

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