Abstract
When radioimmunoassays for LH and FSH were devised, a number of investigators looked for cyclic variations of gonadotropin levels in human plasma. The lack of sensitivity of these initial assays and the failure to obtain frequent samples prevented the detection of variable LH secretion. Nankin and Troen (1) were the first to show that LH and, to some extent, FSH were secreted in a pulsatile fashion. Since these initial studies, numerous laboratories have confirmed that LH secretion is highly variable (2–5). In view of these observations, it was important to determine whether variable gonadotropin secretion occurred in patients and what were the implications of this mode of secretion for the clinician.
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References
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© 1981 ECSC, EEC, EAEC, Brussels-Luxembourg
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Bardin, C.W. (1981). Clinical Implications of Gonadotropin Rhythms. In: van Cauter, E., Copinschi, G. (eds) Human Pituitary Hormones. Developments in Endocrinology, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8282-6_13
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DOI: https://doi.org/10.1007/978-94-009-8282-6_13
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