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Circadian Variation of Plasma Growth Hormone in Normal Subjects and Diabetic Patients. Effects of Somatostatin Infusion, Age and Body Weight

  • Aage Prange Hansen
  • Stig Engkjaer Christensen
Chapter
Part of the Developments in Endocrinology book series (DIEN, volume 1)

Abstract

When these studies were initiated late in 1968 the 24-h plasma growth hormone pattern in normal subjects was just discovered. Hunter and Rigal (1) had reported raised plasma growth hormone values during night in children. Quabbe and coworkers (2) had found in adults low day time plasma growth hormone values, intermittent bursts during night with high peaks occurring during times of deeper sleep. Glick and Goldsmith (3) had shown an effect of various feeding procedures on the 24-h plasma growth hormone level. Takahashi et al. (4) and Honda et al. (5) had demonstrated that the release of growth hormone during night coincides with the onset of electroencephalographically determined deep sleep. Experiments in which they had delayed or interrupted sleep provided evidence that the nocturnal growth hormone secretion was related to the onset of sleep and did not reflect a true endogenous circadian rhythm in growth hormone secretion. Extensive studies by Parker and coworkers (6, 7) have amply confirmed and extended these findings

Keywords

Growth Hormone Growth Hormone Secretion Growth Hormone Level Growth Hormone Release Plasma Growth Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hunter, WM, and WM Rigel, The diurnal pattern of plasma growth hormone concentration in children and adolescents. J Endocrinol 34: 147–153, 1966PubMedCrossRefGoogle Scholar
  2. 2.
    Quabbe, HJ, E Schilling, and H Helde, Pattern of growth hormone secretion during a 24-hour fast in normal adults. J Clin Endocrinol Metab 26: 1173 1177, 1966Google Scholar
  3. 3.
    Glick, SM, and SG Goldsmith, The physiology of growth hormone secretion, In: Growth Hormone, Pecile, A, and EE Müller (eds.). Proceedings of the First International Symposium, Milan, Italy, September 11–13, Amsterdam, Excerpta Medica Foundation, 1968, pp 84–88Google Scholar
  4. 4.
    Takahashi, Y, DM Kipnis, and WH Daughaday, Growth hormone secretion during sleep. J Clin Invest 47: 2079–2090, 1968PubMedCrossRefGoogle Scholar
  5. 5.
    Honda, Y, K Takahashi, S Takahashi, K Azumi, M Irie, M Sakuma, T Tsushima, and K Shizume, Growth hormone secretion during nocturnal sleep in normal subjects. J Clin Endocrinol Metab 29: 20–29, 1969PubMedCrossRefGoogle Scholar
  6. 6.
    Parker, DC, JF Sassin, JW Mace, RW Gatlin, and LG Rossman, Human growth hormone release during sleep Electroecenphalographic correlation. J Clin Endocrinol Metab 29: 871–874, 1969PubMedCrossRefGoogle Scholar
  7. 7.
    Sassin, JF, DC Parker, JW Mace, RW Gotlin, LC Johnson, and LG Rossman, Human growth hormone release: relation to slow-wave sleep and sleep-waking cycles. Science 165: 513–515, 1969PubMedCrossRefGoogle Scholar
  8. 8.
    Lundbaek, K, R Malmros, HC Andersen, JH Rasmussen, E Bruntse, PH Madsen, and VA Jensen, Hypophysectomy for diabetic angiopathy. A controlled clinical trial, In:Supplement to the Proceedings of the Sixth Congress of the International Diabetes Federation, Stockholm, 1967, fstman, J, and RDG Molner (eds.). Amsterdam, Excerpta Medica Foundation, 1969, p 127–139Google Scholar
  9. 9.
    Hansen, AaP, and J Weeke, Fasting serum growth hormone levels and growth hormone responses to exercise during normal menstrual cycles and cycles of oral contraceptives. Scand J Clin Lab Invest 34: 199–205, 1974PubMedCrossRefGoogle Scholar
  10. 10.
    Hansen, AaP, and K Johansen, Diurnal patterns of blood glucose, serum free fatty acids, insulin, glucagon and growth hormone in normals and juvenile diabetics. Diabetologia 6: 27–33, 1970PubMedCrossRefGoogle Scholar
  11. 11.
    Kjeldsen, H, AaP Hansen, and K Lundbaek, Twenty-four hour serum growth hormone levels in maturity-onset diabetics. Diabetes 24: 977–982, 1975PubMedCrossRefGoogle Scholar
  12. 12.
    Johansen, K, and AaP Hansen, Diurnal serum growth hormone levels in poorly and well-controlled juvenile diabetics. Diabetes 20: 239–245, 1971PubMedGoogle Scholar
  13. 13.
    Hansen, AaP, Abnormal serum growth hormone response to exercise in juvenile diabetics. J Clin Invest 49: 1467–1478, 1970PubMedCrossRefGoogle Scholar
  14. 14.
    Hansen, AaP, T Ledet, and K Lundbaek, Growth hormone and diabetes, In:Handbook of Diabetes Mellitus, Brownleed, M (ed.). New York, Garland STPM Press, 1980, in pressGoogle Scholar
  15. 15.
    Hansen, AaP, HE Hansen, H Orskov, R Nosadini, G Noy, and KGMM Alberti, Normalization of growth hormone hypersecretion in uremic diabetics and non-diabetics. Studies with artificial pancreas and artificial kidney, In: Proceedings of the XVIth Congress of the European Dialysis and Transplant Association. Amsterdam, June 1979, in pressGoogle Scholar
  16. 16.
    Parker, DC, and LG Rossman, Human growth hormone release ii sleep: nonsuppression by acute hyperglycemia. J Clin Endocrinol Metab 32: 65–76, 1971PubMedCrossRefGoogle Scholar
  17. 17.
    Parker, DC, and LG Rossman, Sleep release of human growth hormone in treated juvenile diabetics. Similarity to normal subjects and nonsuppression by hyperglycemia. Diabetes 20: 691–695, 1971PubMedGoogle Scholar
  18. 18.
    Schnure, JJ, P Raskin, and RL Lipman, Growth hormone secretion during sleep: impairment in glucose tolerance and nonsuppressibility by hyperglycemia. J Clin Endocrinol Metab 33: 234–241, 1971PubMedCrossRefGoogle Scholar
  19. 19.
    Lucke, C, and SM Glick, Experimental modification of the sleep-induced peak of growth hormone secretion. J Clin Endocrinol Metab 32: 729–736, 1971PubMedCrossRefGoogle Scholar
  20. 20.
    Lucke, C, Adelman, N, and SM Glick, The effect of elevated free fatty acids (FFA) on the sleep-induced human growth hormone (hGH) peak. J Clin Endocrinol Metab 3ç-: 407–412, 1972Google Scholar
  21. 21.
    Lipman, RL, AL Taylor, A Schenk, and DH Mintz, Inhibition of sleep-related growth hormone release by elevated free fatty acids. J Clin Endocrinol Metab 35: 592–594, 1972PubMedCrossRefGoogle Scholar
  22. 22.
    Hansen, AaP, The effect of intravenous glucose infusion on the exercise-induced serum growth hormone rise in normals and juvenile diabetics. Scand J Clin Lab Invest 28: 195–205, 1971PubMedCrossRefGoogle Scholar
  23. 23.
    Hansen, AaP, The effects of intravenous infusion of lipids on the exercise-induced serum growth hormone rise in normals and juvenile diabetics. Scand J Clin Lab Invest 28: 207–212, 1971PubMedCrossRefGoogle Scholar
  24. 24.
    Parker, DC, LG Rossman, TM Siler, J Rivier, SSC Yen, and R Guillemin, Inhibition of the sleep-related peak in physiologic human growth hormone release by somatostatin. J Clin Endocrinol Metab 38: 496499, 1974Google Scholar
  25. 25.
    Christensen, SE, AaP Hansen, J Weeke, and K Lundbaek, 24-hour studies of the effects of somatostatin on the levels of plasma growth hormone, glucagon and glucose in normal subjects and juvenile diabetics. Diabetes 27: 300–306, 1978PubMedCrossRefGoogle Scholar
  26. 26.
    Christensen, SE, AaP Hansen, and K Lundbaek, Somatostatin in maturity-onset diabetes. Diabetes 27: 1013–1019, 1978PubMedCrossRefGoogle Scholar
  27. 27.
    Carlson, HE, JC Gillin, P Gorden, and F Snyder, Absence of sleep-related growth hormone peaks in aged normal subjects and in acromegaly. J Clin Endocrinol Metab 34: 1102–1105, 1972PubMedCrossRefGoogle Scholar
  28. 28.
    Quabbe, HJ, H Helge, and S Kubichi, Nocturnal growth hormone secretion: correlation with sleep in adults and pattern in children and adolescents with non-pituitary dwarfism, overgrowth and with obesity. Acta Endocrinol (Kbh) 67: 767–783, 1971Google Scholar
  29. 29.
    Copinschi, G, MH Delaet, JP Brion, R Leclercq, M L’Hermite, C Robyn, E Virasoro, and E Van Cauter, Simultaneous study of cortisol, growth hormone and prolactin nyctohemeral variations in normal and obese subjects. Influence of prolonged fasting in obesity. Clin Endocrinol (Oxf) 9: 15–26, 1978Google Scholar

Copyright information

© ECSC, EEC, EAEC, Brussels-Luxembourg 1981

Authors and Affiliations

  • Aage Prange Hansen
    • 1
  • Stig Engkjaer Christensen
    • 1
  1. 1.First and Second University Clinic of Internal MedicineKommunehospitaletAarhus CDenmark

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