Abstract
Evidence for a significant familial incidence of Crohn’s disease has been presented from many sources (1–5). Despite this, geneticists have not yet concluded that this familial association has a hereditary basis. The traditional lines of investigation of the past into the etiology of Crohn’s disease such as dietary and psychosomatic have lost their enthusiasts, immunological factors seem to have a supplementary role and even the recently promising microbiological transmission studies warrant less hope than earlier (6). It is therefore understandable for the gastroenterologist to turn once again to his patients to find whether the strong familial association observed clinically is statistically significant and whether any new direction for further investigation might be forthcoming through this route.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Kirsner JB, Spencer JA. (1973) Familial occurrences of ulcerative colitis, regional enteritis and ileocolitis. Ann.Int.Med. 59:133–144
Almy TP, Sherlock P. (1966) Genetic aspects of ulcerative colitis and regional enteritis. Gastroenterology 51:757–763
Singer HC, Anderson JGD, Frischer H, Kirsner JB. (1971) Familial aspects of inflammatory bowel disease. Gastroenterology 61:423–430
Kirsner JB. (1973) Genetic aspects of inflammatory bowel disease. In: Clinics in Gastroenterology. Ed. McConnell RB, WB Saunders, Philadelphia Vol 2: pp 557–575
Farmer RG, Michener WM, Mortimer EA. (1980) Studies of family history among patients with inflammatory bowel disease. In: Clinics in Gastroenterology. Ed. Farmer RG, WB Saunders, Philadelphia Vol 9: pp 271–278
Gitnick GL. (1979) Etiology of inflammatory bowel disease. Are we making progress? Gastroenterology 78:1090–1102
Korelitz BI. (1979) From Crohn to Crohn’s disease:1979. An epidemiological study in New York City. Mt.Sinai J.Med. 46:533–540
Falconer DS. (1965) The inheritance of liability to certain diseases estimated from the incidence among relatives. Ann.Hum.Genet. 29:51–76
Lewkonia RM, McConnell RB. (1976) Familial IBD-heredity or environment? Gut 17:235–243
McConnell RB. (1966) Crohn’s disease and Ulcerative Colitis. In: The Genetics of Gastrointestinal Disorders. Ed. McConnell RB, Oxford Univ. Press, London, pp 128–142
Emery AEH, Lawrence JS. (1974) Genetics of ankylosing spondylitis. J.Med.Genet. 4:239–244
Kemler BJ, Glass D, Alpert E. (1980) HLA studies of families with multiple cases of inflammatory bowel disease [IBD]. Gastroenterology 78:1194
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 Martinus Nijhoff Publishers bv, The Hague
About this chapter
Cite this chapter
Korelitz, B.I. (1981). Epidemiological Evidence for a Hereditary Component in Crohn’s Disease. In: Peña, A.S., Weterman, I.T., Booth, C.C., Strober, W. (eds) Recent Advances in Crohn’s Disease. Developments in Gastroenterology, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8273-4_45
Download citation
DOI: https://doi.org/10.1007/978-94-009-8273-4_45
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-8275-8
Online ISBN: 978-94-009-8273-4
eBook Packages: Springer Book Archive