Abstract
The possible role of mast cells in mediating the tissue lesions of Crohn’s disease [CD] and ulcerative colitis [UC] has been considered by numerous investigators over the last two decades (1–12). That view is fostered by more recent knowledge of the cell biology of the mast cell, e.g., observations that a] its surface contains receptors having a high affinity for the Fc portion of IgE, b] the interaction of the Fab portion of the bound IgE with certain multivalent antigens triggers mast-cell degranulation, and c] the resulting release of chemical mediators directly influences immediate hypersensitivity, tissue repair, and adjacent cellular elements.
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© 1981 Martinus Nijhoff Publishers bv, The Hague
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Matsueda, K., Rimpila, J.J., Ford, H.E., Levin, B., Kraft, S.C. (1981). Tissue Mast Cells in Crohn’s Disease and Ulcerative Colitis. In: Peña, A.S., Weterman, I.T., Booth, C.C., Strober, W. (eds) Recent Advances in Crohn’s Disease. Developments in Gastroenterology, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8273-4_24
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DOI: https://doi.org/10.1007/978-94-009-8273-4_24
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