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Prognostic Significance of the Electrocardiogram in Patients with Coronary Heart Disease

  • Z. Juma
  • A. Castellanos
  • R. J. Myerburg

Abstract

Establishing prognosis in individual coronary heart disease patients is difficult because of the complex pathophysiologic interactions inherent to the disease procers. This difficulty applies as much to specific prognostic information derived from electrocardiography as it does to any other clinical or laboratory method of evaluation. While electrocardiography alone, during and after myocardial infarction, has limitations primarily related to the dynamic characteristics of evolving and healing infarction, there are, nonetheless, valuable prognostic clues which can be recognized. As long as the clinician recognizes the limitations, the electrocardiogram in conjunction with other clinical information does have distinct value both for general and for specific prognostic indices. In this chapter, we summarize the electrocardiographic indices for establishing prognosis in patients with ischemic heart disease, with particular emphasis on myocardial infarction. We analyze available information in three clinical settings: (a) during the acute phase of myocardial infarction, (b) during the convalescent (late hospital) and early posthospital phase, and (c) during the phase of stable ischemic heart disease after surviving myocardial infarction.

Keywords

Acute Myocardial Infarction Ventricular Fibrillation Left Bundle Branch Block Coronary Care Unit Right Bundle Branch Block 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Norris RM, Blandt PWT, Caughey DE, Lee AJ, Scott PJ: A new coronary prognostic index. Lancet 1:274, 1969.PubMedCrossRefGoogle Scholar
  2. 2.
    Blackburn H, Tominaga S: Prognostic importance of electrocardiogram after myocardial infarction. Ann Intern Med 77:677, 1972.Google Scholar
  3. 3.
    Helmers C: Short and long-term prognostic indices in acute myocardial infarction. Acta Med Scand [Suppl] 555:1–80, 1974.Google Scholar
  4. 4.
    Hamosh P, Cohn JM: Left ventricular function in acute myocardial infarction. J Clin Invest 50:523–533, 1971.PubMedCrossRefGoogle Scholar
  5. 5.
    Scheidt S, Ascheim R, Killip T: Shock after acute myocardial infarction. Am J Cardiol 26:556, 1970.PubMedCrossRefGoogle Scholar
  6. 6.
    Scheuer J, Brachfeld N: Coronary insufficiency: relations between hemodynamic, electrical and biochemical parameters. Circ Res 18:178, 1966.Google Scholar
  7. 7.
    Karlsson J, Templeton GH, Willerson JT: Relationship between epicardial ST changes and myocardial metabolism during acute coronary insufficiency. Circ Res 32:725, 1973.PubMedGoogle Scholar
  8. 8.
    Angell CS, Lakatta EG, Weisfeldt ML, Shock NW: Relationship of intramyocardial oxygen tension and epicardial ST segment changes following acute coronary artery ligation. Effects of coronary perfusion pressure. Cardiovasc Res 9:12, 1975.PubMedCrossRefGoogle Scholar
  9. 9.
    Khuri SF, Flaherty JT, O’Riordan JB, Pitt B, Brawley RL, Donahoo JW, Gott VL: Changes in intramyocardial ST segment voltage and tension with regional myocardial ischemia in the dog. Circ Res 37:455, 1975.PubMedGoogle Scholar
  10. 10.
    Maroko PR, Kjekshus JR, Sobel BE, Watanabe T, Covell JW, Ross J Jr, Braunwald E: Factors influencing infarct size following coronary artery occlusions. Circulation 43:67, 1971.PubMedGoogle Scholar
  11. 11.
    Mjos OD, Miller NE, Riemersma RA, Oliver MF: Effects of experimental myocardial ischemic dicloroacetate on myocardial substrate extraction, epicardial ST segment elevation, and ventricular blood flow following coronary occlusion in dogs. Cardiovasc Res 10:427, 1976.PubMedCrossRefGoogle Scholar
  12. 12.
    Nielsen BL: ST segment in acute myocardial infarction: prognostic importance. Circulation 48:338, 1973.PubMedGoogle Scholar
  13. 13.
    Muller JE, Maroko PR, Braunwald E: Precordial electrocardiographic mapping. Circulation 51:1, 1978.Google Scholar
  14. 14.
    London RE, London SB: The electrocardiographic sign of acute hemopericardium. Circulation 25:780, 1962.PubMedGoogle Scholar
  15. 15.
    Wilson FN, MacLeod AG, Baker PS, Johnston PF, Klostermeyer LL: The electrocardiogram in myocardial infarction with particular reference to the initial deflections of the ventricular complex. Heart 16:155, 1933.Google Scholar
  16. 16.
    Hillis LD, Askenazi J, Braunwald E, Radvany P, Miller JE, Fishbein MC, Maroko PR: Use of changes in epicardial QRS complex to assess interventions which modify the extent of myocardial necrosis following coronary artery occlusion. Circulation 54:591, 1976.PubMedGoogle Scholar
  17. 17.
    Humphries JO, Kuller L, Ross RS, Friesinger GC, Page EE: Natural history of ischemic heart disease in relation to artériographie findings: a twelve-year study of 224 patients. Circulation 49:489, 1974.PubMedGoogle Scholar
  18. 18.
    Madias JE, Chahine RA, Gorlin R, Blacklow DJ: A comparison of transmural and non-transmural acute myocardial infarction. Circulation 49:498, 1974.PubMedGoogle Scholar
  19. 19.
    James TN: The coronary circulation and conduction system in acute myocardial infarction. Prog Cardiovasc Dis 10:410, 1968.PubMedCrossRefGoogle Scholar
  20. 20.
    Rotman M, Wagner GS, Wallace AG: Bradyarrhythmias in acute myocardial infarction. Circulation 45:703, 1972.PubMedGoogle Scholar
  21. 21.
    Pantridge JF, Adgee AAJ, Geddes JS: The acute coronary attack. New York, Grune and Stratton, 1976.Google Scholar
  22. 22.
    Friedberg CK, Cohen M, Donoso E: Advanced heart block as a complication of acute myocardial infarction: role of pacemaker therapy. Prog Cardiovasc Dis 10:466, 1968.PubMedCrossRefGoogle Scholar
  23. 23.
    Rosen KM, Loeb MS, Chuquimia R, Sinno MZ, Rahimtoola SH, Gunnar RM: Site of heart block in acute myocardial infarction. Circulation 42:925, 1970.PubMedGoogle Scholar
  24. 24.
    Langendorf R, Pick A: Atrioventricular block, type II Mobitz: its nature and clinical significance. Circulation 38:819, 1968.PubMedGoogle Scholar
  25. 25.
    Mullins CB, Atkins JM: Prognoses and management of ventricular conduction blocks in acute myocardial infarction. Mod Concepts Cardiovasc Dis 45:129, 1976.PubMedGoogle Scholar
  26. 26.
    Atkins JM, Leshin SJ, Blomqvist CG, Mullins CB: Ventricular conduction blocks and sudden death in acute myocardial infarction. Potential indications for pacing. N Engl J Med 288:281, 1973.PubMedCrossRefGoogle Scholar
  27. 27.
    Col JJ, Weinberg SL: Incidence and mortality of intraventricular conduction defects in acute myocardial infarction. Am J Cardiol 29:344, 1972.PubMedCrossRefGoogle Scholar
  28. 28.
    Scheinman M, Brenman B: Clinical and anatomic implications of intraventricular conduction blocks in acute myocardial infarction. Circulation 46:753, 1972.PubMedGoogle Scholar
  29. 29.
    Nimetz AA, Shubrooks SJ Jr, Hutter AM Jr, DeSanctis RW: Significance of bundle branch block during acute myocardial infarction. Am Heart J 90:439, 1975.PubMedCrossRefGoogle Scholar
  30. 30.
    Waugh RA, Wagner GS, Haney TL, Rosati RA, Morris JJ Jr: Immediate and remote prognostic significance of fascicular block during acute myocardial infarction. Circulation 47:765, 1973.PubMedGoogle Scholar
  31. 31.
    Waters DD, Mizgala HF: Long-term prognosis of patients with incomplete bilateral bundle branch block complicating acute myocardial infarction: role of cardiac pacing. Am J Cardiol 34:1, 1974.PubMedCrossRefGoogle Scholar
  32. 32.
    Norris RM, Mercer CJ, Croxson MS: Conduction disturbances due to antero-septal myocardial infarction and their treatment by endocardial pacing. Am Heart J 84:560, 1972.PubMedCrossRefGoogle Scholar
  33. 33.
    Godman MJ, Lassers BW, Julian DG: Complete bundle branch block complicating acute myocardial infarction. N Engl J Med 282:237, 1970.PubMedCrossRefGoogle Scholar
  34. 34.
    Scanlon PJ, Pryor R, Blount SG Jr: Right bundle branch block associated with left superior or inferior intraventricular block: associated with acute myocardial infarction. Circulation 42:1135, 1970.PubMedGoogle Scholar
  35. 35.
    Hindman MC, Wagner GS, JaRo AB, Atkins JM, Scheinman MM, DeSanctis RW, Hutter AH, Yeatman L, Rubenfire M, Pujura C, Rubin M, Morris JJ: The clinical significance of bundle branch block complicating acute myocardial infarction: 1. Clinical characteristics, hospital mortality, and one-year follow-up. Circulation 58:679, 1978.PubMedGoogle Scholar
  36. 36.
    Lie KI, Wellens HJJ, Schuilenburg RM: Bundle branch block and myocardial infarction. In: Wellens HJJ, Lie KI, Janse MJ (eds) The conduction system of the heart. Leiden, Stenfert Kroese 1976.Google Scholar
  37. 37.
    Roos JC, Dunning AJ: Bundle branch block in acute myocardial infarction. Eur J Cardiol 6:504, 1978.Google Scholar
  38. 38.
    Hindman MC, Wagner GS, JaRo M, Atkins JM, Scheinman MM, DeSanctis RW, Hutter AH, Yeatman L, Rubenfire M, Pujura C, Rubin M, Morris JJ: The clinical significance of bundle branch block complicating acute myocardial infarction: II. Indications for temporary and permanent pacemaker therapy. Circulation 58:689, 1978.PubMedGoogle Scholar
  39. 39.
    Lie KI, Wellens HJJ, Schuilenburg RM: Factors influencing prognosis of bundle branch block complieating acute myocardial infarction. Circulation 50:935, 1974.PubMedGoogle Scholar
  40. 40.
    Biddle TL, Ehrich DA, Yu PN, Hodges M: Relation of heart block and left ventricular dysfunction in acute myocardial infarction. Am J Cardiol 39:961, 1977.PubMedCrossRefGoogle Scholar
  41. 41.
    Gann D, Balachandran PK, El-Sherif N, Samet P: Prognostic significance of chronic versus acute bundle branch block in acute myocardial infarction. Chest 67:298, 1975.PubMedCrossRefGoogle Scholar
  42. 42.
    Sutton R, Davies M: The conduction system in acute myocardial infarction complicated by heart block. Circulation 38:987, 1968.PubMedGoogle Scholar
  43. 43.
    Lown B, Kosowsky BD: Artificial cardiac pacemakers. N Engl J Med 283:907, 971, 1023, 1970.PubMedCrossRefGoogle Scholar
  44. 44.
    Meltzer LE, Cohen ME: The incidence of arrhythmias associated with acute myocardial infarction. In: Meltzer LE, Dunning AJ (eds) Textbook of coronary care. Amsterdam, Excerpta Medica, 1972, p 107.Google Scholar
  45. 45.
    Hunt D, Lie JT, Vohra J, Sloman G: Histopathology of heart block complicating acute myocardial infarction. Correlation with His bundle electrogram. Circulation 48:1252, 1973.PubMedGoogle Scholar
  46. 46.
    Tans AC, Lie KI: AV nodal block in acute myocardial infarction. In: Wellens HJJ, Lie KI, Janse MJ (eds) The conduction system of the heart. Leiden, Stenfert Kroese, 1976.Google Scholar
  47. 47.
    Norris RM, Mercer CJ: Significance of idioventricular rhythm in acute myocardial infarction. Prog Cardiovasc Dis 16:455, 1974.PubMedCrossRefGoogle Scholar
  48. 48.
    Rotman M, Wagner GS, Waugh RA: Significance of high degree atrioventricular block in acute posterior myocardial infarction. Circulation 47:257, 1973.PubMedGoogle Scholar
  49. 49.
    Lie KI, Durrer D: Conduction disturbances in acute myocardial infarction. In: Narula OS (ed) Textbook of cardiac arrhythmias, 1979, p 140.Google Scholar
  50. 50.
    Rosen KM, Loeb HS, Chuquimia R, Sinno MZ, Rahimtoola SH, Gunnar RM: Site of heart block in acute myocardial infarction. Circulation 42:925, 1970.PubMedGoogle Scholar
  51. 51.
    Wit AL, Bigger JT Jr: Possible electrophysiological mechanisms for lethal arrhythmias accompanying myocardial ischemia and infarction. Circulation [Suppl 3] 52:96, 1975.Google Scholar
  52. 52.
    George M, Greenwood TW: Relation between bradycardia and the site of myocardial infarction. Lancet 2:739, 1967.PubMedCrossRefGoogle Scholar
  53. 53.
    Cox JR Jr, Roberts R, Ambros HD, Oliver GC, Sobel BE: Relations between enzymatically estimated myocardial infarct size and early ventricular dysrhythmia. Circulation [Suppl 1] 53:150, 1976.Google Scholar
  54. 54.
    Adgey AAJ, Geddes JS, Mulholland MC, Keegan DAJ, Pantridge JF: Incidence, significance and management of early bradyarrhythmia complicating acute myocardial infarction. Lancet 2:1097, 1968.PubMedCrossRefGoogle Scholar
  55. 55.
    Adgey AAJ, Pantridge JF: Acute phase of myocardial infarction. Lancet 2:501, 1971.PubMedCrossRefGoogle Scholar
  56. 56.
    Corr P, Gillis R: Autonomic neural influences on the dysrhythmias resulting from myocardial infarction. Circ Res 43:1, 1978.PubMedGoogle Scholar
  57. 57.
    Lewis RP, Warren JV: Factors determining mortality in the prehospital phase of acute myocardial infarction. Am J Cardiol 33:152, 1974.CrossRefGoogle Scholar
  58. 58.
    Norris RM, Mercer CJ, Yeater SE: Sinus rate in acute myocardial infarction. Br Heart J 34:901, 1972.PubMedCrossRefGoogle Scholar
  59. 59.
    Warren JV, Lewis RP: Beneficial effects of atropine in the prehospital phase of coronary care. Am J Cardiol 37:68, 1976.PubMedCrossRefGoogle Scholar
  60. 60.
    Lown B, Vassaux C, Hood WB Jr. Fakhro AM, Kaplinsky E, Roberge G: Unresolved problems in coronary care. Am J Cardiol 20:494, 1967.PubMedCrossRefGoogle Scholar
  61. 61.
    Epstein SE, Goldstein RE, Redwood DR, Kent KM, Smith ER: The early phase of acute myocardial infarction: pharmacologic aspects of therapy. Ann Intern Med 78:198, 1973.Google Scholar
  62. 62.
    Myers RW, Pearlman AS, Hyman RM, Goldstein RA, Kent KM, Goldstein RE, Epstein SE: Beneficial effects of vagal stimulation and bradycardia during experimental acute myocardial infarction. Circulation 49:943, 1974.PubMedGoogle Scholar
  63. 63.
    Han J, DeTraglia J, Millet D, Moe GK: Incidence of ectopic beats as a function of basic rate in the ventricle. Am Heart J 72:632, 1966.PubMedCrossRefGoogle Scholar
  64. 64.
    Han J, Millet D, Chizzonitti B, Moe GK: The early phase of acute myocardial infarction: pharmacologic aspects of therapy. Am Heart J 71:481, 1966.PubMedCrossRefGoogle Scholar
  65. 65.
    Jarisch A, Zotteman Y: Depressor reflexes from the heart. Acta Physiol Scand 16:31, 1948.CrossRefGoogle Scholar
  66. 66.
    Frink RJ, James TN: Intracardiac route of the Bezold-Jarisch reflex. Am J Physiol 221:1464, 1971.PubMedGoogle Scholar
  67. 67.
    James TN: Cardiac innervation: anatomic and pharmacologic relationships. Bull NY Acad Med 43:1041, 1967.Google Scholar
  68. 68.
    Costatin L: Extracardiac factors contributing to hypotension during coronary occlusion. Am J Cardiol 11:205, 1963.CrossRefGoogle Scholar
  69. 69.
    Meitzer LE, Cohen HE: The incidence of arrhythmias associated with acute myocardial infarction. In: Meltzer LE, Dunning AJ (eds) Textbook of coronary care. Amsterdam, Excerpta Medica, 1972, p 107.Google Scholar
  70. 70.
    Julien DG, Valentine PA, Miller GG: Disturbances of rate, rhythm, conduction in acute myocardial infarction. Am J Med 37:915, 1964.CrossRefGoogle Scholar
  71. 71.
    James TN: Myocardial infarction and atrial arrhythmias. Circulation 24:761, 1961.PubMedGoogle Scholar
  72. 72.
    DeSanctis RW, Block P, Hutter AM: Tachyarrhythmias in myocardial infarction. Circulation 45:681, 1972.PubMedGoogle Scholar
  73. 73.
    Jewitt DE, Balcon R, Raftery EB, Balcon R, Olam S: Incidence and management of supraventricular arrhythmias after acute myocardial infarction. Lancet 2:734, 1967.PubMedCrossRefGoogle Scholar
  74. 74.
    Lie KI, Durrer D: Common arrhythmias in acute myocardial infarction. Cardiovasc Clin 11:191, 1980.PubMedGoogle Scholar
  75. 75.
    Chapman BL: Prognostic factors in acute myocardial infarction treated in a coronary care unit. Aust NZ J Med 1:53, 1971.CrossRefGoogle Scholar
  76. 76.
    Helmers C, Lundman T, Mogensen L, Orinius E, Sjogren A, Wester PO: Atrial fibrillation in acute myocardial infarction. Acta Med Scand 193:39, 1973.PubMedCrossRefGoogle Scholar
  77. 77.
    Norris RM, Mercer CJ: Long-term prognosis following treatment in a coronary care unit. Aust NZ J Med 1:31, 1973.CrossRefGoogle Scholar
  78. 78.
    Lown B, Fakhro A, Hood WB, Thorn GW: The coronary care unit: new perspective and directions. JAMA 199:188, 1967.PubMedCrossRefGoogle Scholar
  79. 79.
    Mogenson L: Ventricular tachyarrhythmias and lignocaine prophylaxis in acute myocardial infarction. Acta Med Scand [Suppl] 1:513, 1970.Google Scholar
  80. 80.
    Williams DO, Scherlag BJ, Hope RR, El-Sherif N, Lazzara R: The pathophysiology of malignant ventricular arrhythmias during acute myocardial ischemia. Circulation 50:1163, 1974.PubMedGoogle Scholar
  81. 81.
    Lie KI, Wellens HJJ, Downar E, Durrer D: Observation on patients with primary ventricular fibrillation complicating acute myocardial infarction. Circulation 52:755, 1975.PubMedGoogle Scholar
  82. 82.
    Roberts R, Ambos HD, Loh CW, Sobel BE: Initiation of repetitive ventricular depolarization by relatively late premature complexes in patients with acute myocardial infarction. Am J Cardiol 41:678, 1978.PubMedCrossRefGoogle Scholar
  83. 83.
    Vismara LA, DeMaria AN, Hughes JL, Mason DT, Amsterdam EA: Evaluation of arrhythmias in the late hospital phase of acute myocardial infarction compared to coronary care unit ectopy. Br Heart J 37:598, 1975.CrossRefGoogle Scholar
  84. 84.
    Bigger JT, Dresdale RJ, Heissenbuttel RM, Weld FM, Wit AL: Ventricular arrhythmias in ischemic heart disease: mechanisms, prevalence, significance and management. Prog Cardiovasc Dis 19:255, 1977.PubMedCrossRefGoogle Scholar
  85. 85.
    Norris RM, Mercer RJ: Significance of idioventricular rhythm in acute myocardial infarction. Prog Cardiovasc Dis 16:455, 1974.PubMedCrossRefGoogle Scholar
  86. 86.
    Lichstein E, Ribas-Menclier C, Gupta PK: Incidence and description of accelerated ventricular rhythm complicating acute myocardial infarction. Am J Med 58:192, 1975.PubMedCrossRefGoogle Scholar
  87. 87.
    Pantridge JF, Geddes JS: Primary ventricular fibrillation. Eur J Cardiol 1:335, 1974.PubMedGoogle Scholar
  88. 88.
    Reid PR, Taylor DR, Kelly DT, Weisfeldt ML, Humphries JO, Ross RS, Pitt B: Myocardial infarct extension detected by precordial ST segment mapping. N Engl J Med 290:123, 1974.PubMedCrossRefGoogle Scholar
  89. 89.
    Scherf D, Boyd JJ: Cardiac aneurysm. Med Clin North Am 26:919, 1942.Google Scholar
  90. 90.
    Rosenberg B, Messinger WJ: The electrocardiogram in ventricular aneurysm. Am Heart J 37:267, 1949.PubMedCrossRefGoogle Scholar
  91. 91.
    Steven RA: Electrocardiographic findings in cardiac aneurysms. Ann Intern Med 34:747, 1951.PubMedGoogle Scholar
  92. 92.
    Ford RV, Levine HO: The electrocardiographic clue to ventricular aneurysm. Ann Intern Med 34:998, 1951.PubMedGoogle Scholar
  93. 93.
    Mills RM Jr, Young E, Gorlin R, Lesch M: Natural history of ST segment elevation after acute myocardial infarction. Am J Cardiol 35:609, 1975.PubMedCrossRefGoogle Scholar
  94. 94.
    Lichstein E, Gupta PK, Chadda KD: Long-term survival of patients with incomplete bundle branch block complicating acute myocardial infarction. Br Heart J 37:924, 1975.PubMedCrossRefGoogle Scholar
  95. 95.
    Lie KI, Schuilenburg RM, David GK, Durrer D: A 51/2year retro-and prospective study on early identification of candidates developing late in-hospital ventricular fibrillation. Am J Cardiol 41:674, 1978.PubMedCrossRefGoogle Scholar
  96. 96.
    Morris JJ Jr: Immediate and remote prognostic significance of fascicular block during acute myocardial infarction. Circulation 47:765, 1973.PubMedGoogle Scholar
  97. 97.
    Moss AJ, De Camilla J, Davis H, Bayer L: The early post-hospital phase of myocardial infarction. Prognostic stratification. Circulation 54:48, 1976.Google Scholar
  98. 98.
    Vismara LA, Amsterdam EA, Mason DT: Relationship of ventricular arrhythmias in the late hospital phase of acute myocardial infarction to sudden death after hospital discharge. Am J Med 59:6, 1975.PubMedCrossRefGoogle Scholar
  99. 99.
    Oliver GC, Nolle FM, Tiefenbrunn AJ, Kleiger RE, Martin TF, Krome RJ, Miller JP, Cox JR: Ventricular arrhythmias associated with sudden death in survivors of acute myocardial infarction [abstr]. Am J Cardiol 33:160, 1974.CrossRefGoogle Scholar
  100. 100.
    Kolter MN, Tabatznik B, Mower MM, Taminaza S: Prognostic significance of ventricular ectopic beats with respect to sudden death in the late post-infarction period. Circulation 47:959, 1973.Google Scholar
  101. 101.
    Ruberman W, Weinblatt E, Goldberg JD, Frank CW, Shapiro S: Ventricular premature beats and mortality after myocardial infarction. N Engl J Med 297:750, 1977.PubMedCrossRefGoogle Scholar
  102. 102.
    Lawrie DM: Long-term survival after ventricular fibrillation complicating acute myocardial infarction. Lancet 2:1085, 1969.PubMedCrossRefGoogle Scholar
  103. 103.
    Thompson P, Sloman G: Sudden death in hospital after discharge from coronary care unit. Br Med J 4:136, 1971.PubMedCrossRefGoogle Scholar
  104. 104.
    Wilson C, Pantridge JF: ST segment displacement and early hospital discharge in acute myocardial infarction. Lancet 2:1284, 1973.PubMedCrossRefGoogle Scholar
  105. 105.
    Wilson C, Adgey AJJ: Survival of patients with late ventricular fibrillation after acute myocardial infarction. Lancet 2:124, 1974.PubMedCrossRefGoogle Scholar
  106. 106.
    Bornheimer J, DeGuzman M, Haywood J: Analysis of in-hospital deaths from myocardial infarction after coronary care unit discharge. Arch Intern Med 135:1035, 1975.PubMedCrossRefGoogle Scholar
  107. 107.
    Block WJ Jr, Crumpacher EL, Dry TJ, Gage RP: Prognosis of angina pectoris: observations in 6,882 cases. JAMA 150:259, 1952.Google Scholar
  108. 108.
    Haynes RE, Hallstrom AP, Cobb LA: Repolarization abnormalities in survivors of out-of-hospital ventricular fibrillation. Circulation 57:654, 1978.PubMedGoogle Scholar
  109. 109.
    Schwartz PJ, Periti M, Malliani A: The long QT syndrome. Am Heart J 89:378, 1975.PubMedCrossRefGoogle Scholar
  110. 110.
    Schwartz PJ, Wolf S: QT interval prolongation as predictor of sudden death in patients with myocardial infarction. Circulation 57:1074, 1978.PubMedGoogle Scholar

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© Martinus Nijhoff Publishers, The Hague 1981

Authors and Affiliations

  • Z. Juma
  • A. Castellanos
  • R. J. Myerburg

There are no affiliations available

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