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Biological Markers of the Tumors of the Central Nervous System

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Pediatric Oncology 1

Part of the book series: Cancer Treatment and Research ((CTAR,volume 2))

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Abstract

The concept of biochemical tumor markers began with Warburg’s research on the differences in enzymatic activities between normal and neoplastic tissues from the same organ [1]. His observation that rates of aerobic glycolysis were higher for tumor tissue than for normal, nongrowing tissue was subsequently shown to depend on the degree of differentiation of the tumor [2]. Other enzymatic differences between cancer and normal cells have been reported and were reviewed recently by Weber [2]. Such intracellular differences might be reflected in alterations of the activities of specific enzymes or concentrations of specific biomolecules in physiological fluids. Because the cerebrospinal fluid (CSF) is most directly in contact with central nervous system (CNS) tissue, and because the existence of a blood-brain barrier has long been known, metabolic changes associated with neoplasms of the CNS may be observed earlier and to a greater degree in CSF than in other physiological fluids such as urine or serum. Nevertheless, several published studies on CNS tumor markers in serum and/or urine will be included in this review.

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  1. Jerome Seidenfeld
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  2. Laurence J. Marton
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Editors and Affiliations

  1. Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26901, Oklahoma City, OK, 73190, USA

    G. Bennett Humphrey

  2. Department of Laboratory Medicine and Pathology, Division of Surgical Pathology, University of Minnesota Medical School, Box 609, Mayo Memorial Building, 420 Delaware Street, S.E., Minneapolis, MN, 55455, USA

    Louis P. Dehner

  3. New York State University at Buffalo, USA

    Gerald B. Grindey

  4. Diabetes Research & Training Center, University of Alabama in Birmingham, 1808 Seventh Avenue South, University Station, Birmingham, AL, 35291, USA

    Ronald T. Acton

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© 1981 Martinus Nijhoff Publishers

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Seidenfeld, J., Marton, L.J. (1981). Biological Markers of the Tumors of the Central Nervous System. In: Humphrey, G.B., Dehner, L.P., Grindey, G.B., Acton, R.T. (eds) Pediatric Oncology 1. Cancer Treatment and Research, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8219-2_5

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  • DOI: https://doi.org/10.1007/978-94-009-8219-2_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8221-5

  • Online ISBN: 978-94-009-8219-2

  • eBook Packages: Springer Book Archive

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