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Uptake and Stimulated Release of Taurine by Preparations of Cerebral Cortex

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Part of the book series: Monographs of the Physiological Society of Philadelphia ((MPSP,volume 7))

Abstract

Taurine occurs at high concentrations in neural tissue, for example, at about 8 μmol/g in rat cerebral cortex (Lombardini, 1976). Its role in the cerebral cortex remains obscure, although it has been proposed to act there as a neurotransmitter (Davison and Kaczmarek, 1971; Mandel and Pasantes-Morales, 1978). Its potent neuronal inhibitory properties support this possibility (Curtis and Watkins, 1960, 1965; Okamoto and Quastel, 1973).

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References

  • Agrawal, H. C.; Davidson, N. A.; and Kazcmarek, L. K. Subcellular distribution of taurine and cysteinsulphinate decarboxylase in developing rat brain. Biochem. J., 122, 759–763 (1977).

    Google Scholar 

  • Berger, F.; Urban, R. F.; and Mandel, P. Potassium evoked release of [14C]GABA and [3H]taurine from rat ofactory bulb slices. Neuro. Sci. Lett., 8, 1137–1142 (1978).

    Google Scholar 

  • Bowery, N. G.; and Brown, D. A. γ-Aminobutyric acid uptake by sympathetic ganglia. Nature. New Biol., 238, 89–91 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Bradford, H. F.; Bennet, G. W.; and Thomas, A. J. Depolarizing stimuli and the release of physiologically active amino acids from suspensions of mammalian synaptosomes. J. Neurochem.,21, 495–505 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Bradford, H. F.; Davison, A. N.; and Wheler, G. H. T. Taurine and synaptic transmission. In Taurine, ed. by R. Huxtable and A. Barbeau. Raven Press, New York, pp. 303–310 (1976).

    Google Scholar 

  • Collins, G. G. S. The release of endogenous amino acids from rat visual cortex by calcium ions in the presence of calcium iosoptoes X537 and A23187. J. Neurochem., 28, 461–463 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Curtis, D. R.; and Watkins, J. C. The excitation and depression of spinal neurones by structurally related amino acids. J. Neurochem., 6, 117–141 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Curtis, D. R.; and Watkins, J. C. The pharmacology of amino acids related to gamma-amino-butyric acid Pharmac. Rev.,17, 347–391 (1965).

    CAS  Google Scholar 

  • De Belleroche, J. S.; and Bradford, H. F. Metabolism of beds of mammalian cortical synaptosomes: Response to depolarizing influences. J. Neurochem., 19, 585–602 (1972).

    Article  PubMed  Google Scholar 

  • De Belleroche, J. S.; and Bradford, H. F. Amino acids in synaptic vesicles from mammalian cerebral cortex: A reappraisal. J. Neurochem., 21, 441–451 (1973).

    Article  PubMed  Google Scholar 

  • Davison, A. N.; and Kaczmarek, L. K. Taurine-A possible neurotransmitter? Nature,234, 107–108 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Dick, F.; and Kelly, J. S. L-2,4-Diaminobutyric acid (L-DABA) as a selective marker for inhibitory nerve terminals in rat brain. Br. J. Pharmacol., 53, 439 (1975).

    Google Scholar 

  • Ehinger, B. Glial uptake of taurine in the rabbit retina. Brain Res., 60, 512–516 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Iversen, L. L.; and Bloom, F. E. Studies of the uptake 3H-GABA and 3H-glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography. Brain Res., 41, 131–143 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Iversen, L. L.; and Johnson, G. A. R. GABA uptake in rat central nervous system: Comparison of uptake in slices and homogenates and the effects of some inhibitors. J. Neurochem., 18, 1939–1950 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Iversen, L. L.; Kelly, J. S.; Minchin, M.; Schon, F.; and Snodgrass, S. R. Role of amino acids and peptides in synaptic transmission. Brain Res., 62, 567–576 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Kaczmarek, L. K.; and Davison, A. N. Uptake and release of taurine from rat brain slices. J. Neurochem., 19, 2355–2362 (1972).

    Article  CAS  Google Scholar 

  • Lähdesmäki, P.; and Oja, S. S. On the mechanism of taurine transport at brain cell membranes. J. Neurochem.., 20, 1411–1417 (1973).

    Article  PubMed  Google Scholar 

  • Lombardini, J. B. Regional and subcellular studies on taurine in the rat CNS. In Taurine,ed. by R. Huxtable and A. Barbeau. Raven Press, New York, pp. 311–326 (1976).

    Google Scholar 

  • Lombardini, J. B. High affinity uptake systems for taurine in tissue slices and synaptosome fractions prepared from various regions of the rat CNS: Correction of transport data by different experimental procedures. J. Neurochem, 29, 305–312 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Lowry, O. H.; Rosenbrough, N. J.; Farr, A. L.; and Randall, J. R. Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265–275 (1951).

    PubMed  CAS  Google Scholar 

  • Mandel, P.; and Pasantes-Morales, H. The role of taurine in the central nervous system. In Reviews of Neuroscience, ed. by S. Ehrenpreis and I. Kopin. Raven Press, New York, pp. 157–193 (1978).

    Google Scholar 

  • McIlwain, H. Metabolic experiments with neural tissues. In Practical Neurochemistry. Churchill Livingstone, p. 150 (1975).

    Google Scholar 

  • Okamoto, K.; and Quastel, J. H. Spontaneous action potentials in isolated guinea pig cerebellar slices: Effects of amino acids and conditions affecting sodium and water uptake. Proc. Royal Soc. Lond. B, 184, 83–90 (1973).

    Article  CAS  Google Scholar 

  • Pasantes-Morales, H.; Salceda, R.; and Gomez-Puyona. Effect of X537A on the release of amino acids in retina. Biochim. Biophys. Res. Comm., 58, 847–853 (1974).

    Article  CAS  Google Scholar 

  • Peck, E. J.; and Awapara, J. Formation of taurine and isethionic acid in rat brain. Biochim. Biophys. Acta, 141, 499–506 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Rassin, D. K.; Sturman, J. A.; and Gaull, G. E. Taurine in developing rat brain: Subcellular distribution and association with synaptic vesicles of 35S-taurine in maternal, fetal and neonatal rat brain. J. Neurochem., 28, 41–50 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Schmid R.; Sieghart, W.; and Karobath, M. Taurine uptake in synaptosomal fractions of rat cerebral cortex. J. Neurochem., 25, 5–9 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Schon, F.; and Kelly, J. S. Selective uptake of 3H-ß-alanine by glia: Association with the glial uptake system for GABA. Brain Res., 86, 243–257 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Schrier, N. K.; and Thompson, E. J. On the role of glial cells in the mammalian nervous system. J. Biol. Chem., 249, 1769–1780 (1974).

    PubMed  CAS  Google Scholar 

  • Sellstrom, A.; and Hamberger, A. Potassium-stimulated γ-aminobutyric acid release from neurons and glia. Brain Res., 119, 189–198 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Sieghart, W.; and Heckl, L. Potassium-evoked release of taurine from synaptosomal fractions of rat cerebral cortex. Brain Res., 116, 538–543 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Sieghart, W.; and Karobath, M. Evidence for specific synaptosomal localization of endogenous accumulated taurine. J. Neurochem., 23, 911–915 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Snodgrass, S. R.; Hedley-Whyte, T. E.; and Lorenzo, A. V. GABA transport by nerve ending-fractions of rat brain. J. Neurochem., 20, 771–782 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Weinreich, D.; and Hammerschlag, R. Nerve impulse-enhanced release of amino acids from non-synaptic regions of peripheral and central nerve trunks of bullfrog. Brain Res., 84, 137–142 (1973).

    Article  Google Scholar 

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© 1981 Spectrum Publications, Inc.

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Wheler, G.H.T., Bradford, H.F., Davison, A.N., Thompson, E.J. (1981). Uptake and Stimulated Release of Taurine by Preparations of Cerebral Cortex. In: Schaffer, S.W., Baskin, S.I., Kocsis, J.J. (eds) The Effects of Taurine on Excitable Tissues. Monographs of the Physiological Society of Philadelphia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8093-8_9

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  • DOI: https://doi.org/10.1007/978-94-009-8093-8_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8095-2

  • Online ISBN: 978-94-009-8093-8

  • eBook Packages: Springer Book Archive

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