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Effects of Taurine on Subcellular Calcium Dynamics in the Normal and Cardiomyopathic Hamster Heart

  • Chapter
The Effects of Taurine on Excitable Tissues

Part of the book series: Monographs of the Physiological Society of Philadelphia ((MPSP,volume 7))

Abstract

It has been considered for some time that the molecular basis of heart failure may be broadly categorized into defects in energy production or defects in energy utilization (Olson, 1959). Even though defects in energy production have been demonstrated in some instances, energy stores in general have been reported to be normal in many models of heart failure (Wollenberger, 1949). The excitation-contraction coupling component of energy utilization has long been suspected to have a role in the failing heart mechanism (Nayler, 1963). Calcium has been considered to play a central role in this excitation-contraction process, and recently Dhalla (1976) has suggested that both calcium deficiency and calcium overload within the cardiac cells may be involved in the mechanism of heart failure.

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References

  • Anand, M. B.; Chauhan, M. S.; and Dhalla, N. S. Ca+2/Mg+2 ATPase activities of heart sarcolemma, microsomes, and mitochondria. J. Biochem., 82, 1731–1739 (1977).

    PubMed  CAS  Google Scholar 

  • Appelt, A. W.; Welty, J. D.; and Peterson, M. B. Changes in sarcolemmal and sarcoplasmic reticulum ATPase activities with age in the cardiomyopathy Syrian hamster. J. Mol. Cell. Cardiol, 8, 901–907 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Bajusz, E. Dystrophic calcification of myocardium as conditioning factor in genesis of congestive heart failure: An experimental study. Am. Heart J., 78, 202–210 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Bajusz, E.; and Lossnitzer, K. A new disease model of chronic congestive heart failure: Studies on its pathogenesis. Trans. N.Y. Acad. Sci, 30 (Sec. II), 939–948 (1968).

    PubMed  CAS  Google Scholar 

  • Bajusz, E.; Baker, J. R.; Nixon, C. W.; and Homburger, F. Spontaneous hereditary myocardial degeneration and congestive heart failure in the Syrian hamster. Ann. N.Y. Acad. Sci, 156, 105–129 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Carafoli, E. Mitochondria in the contraction and relaxation of heart. In Myocardial Biology, Vol. 4, N. S. Dhalla, ed. University Park Press, Baltimore (1974), pp. 393–406.

    Google Scholar 

  • Carafoli, E.; and Crompton, M. The regulation of intracellular calcium. In Current Topics in Membranes and Transport, F. Bronner and A. Kleinzeller, eds. Academic Press, New York (1978a), pp. 151–216.

    Google Scholar 

  • Carafoli, E.; and Crompton, M. The regulation of intracellular calcium by mitochondria. Ann. N.Y. Acad. Sci, 307, 269–284 (1978b).

    Article  PubMed  CAS  Google Scholar 

  • Carafoli, E.; Tiozzo, R.; Crovetti, L. F.; and Kratzing, C. The release of calcium from heart mitochondria by sodium. J. Mol. Cell. Cardiol, 6, 361–371 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Dhalla, N. S. Defects in calcium regulatory mechanisms in heart failure. In Myocardial Biology, Vol. 4, N. S. Dhalla, ed. University Park Press, Baltimore (1974), pp. 521–534.

    Google Scholar 

  • Dhalla, N. S. Involvement of membrane systems in heart failure due to intracellular calcium overload and deficiency. J. Mol. Cell. Cardiol., 8, 661–667 (1976).

    Article  CAS  Google Scholar 

  • Dhalla, N. S.; Tomlinson, C. W.; Singh, J. N.; Lee, S. L.; McNamara, D. B.; Harrow, J. A. C; and Yates, J. C. Role of sarcolemmal changes in cardiac pathophysiology. In The Sarcolemma, P. Roy and N. S. Dhalla, eds. University Park Press, Baltimore (1976), pp. 377–394.

    Google Scholar 

  • Dhalla, N. S.; Das, P. K.; and Sharma, G. P. Subcellular basis of cardiac failure. J. Mol. Cell. Cardiol., 10, 363–385 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Dietrich, J.; and Diacono, J. Comparison between ouabain and taurine effects on isolated rat and guinea pig hearts in low calcium medium. Life Sci., 10, 499–508 (1971).

    Article  CAS  Google Scholar 

  • Dolara, P.; Agresti, A.; Giotti, A.; and Pasquini, G. Effect of taurine on calcium kinetics of guinea-pig heart. Eur. J. Pharm., 24, 352–358 (1973).

    Article  CAS  Google Scholar 

  • Guidotti, A.; Bandiani, G.; and Giotti, A. Potentiation by taurine of inotropic effect of strophanthine on guinea-pig isolated auricles. Pharm. Res. Comm., 3, 29–38 (1971).

    Article  CAS  Google Scholar 

  • Hui, C. W.; Drummond, M.; and Drummond, G. I. Calcium accumulation and cyclic AMP stimulated phosphorylation in plasma membrane-enriched preparations of myocardium. Arch. Biochem. Biophys., 173, 415–427 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Huxtable, R.; and Bressler, R. Taurine concentrations in congestive heart failure. Science, 184, 1187–1188 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Kagawa, Y.; and Racker, E. Partial resolution of the enzyme catalyzing oxidative phosphorylation. J. Biol. Chem., 246, 5477–5490 (1971).

    CAS  Google Scholar 

  • Katz, A. M. Congestive heart failure: Role of altered myocardial cellular control. N. Engl. J. Med., 293, 1184–1191 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Katz, A. M.; Repke, D. I.; Upshaw, J. E.; and Polascik, M. A. Use of zonal centrifugation to fractionate fragmental sarcoplasmic reticulum, (Na+-K+)-activated ATPase and mitochondrial fragments. Biochim. Biophys. Acta, 205, 473–490 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Kramer, C. Y. Extension of multiple range tests to group means with unequal numbers of replication. Biometrics, 12, 307–310 (1956).

    Article  Google Scholar 

  • Kulakowski, E. C; Maturo, J.; and Schaffer, S. W. The identification of taurine receptors from rat heart sarcolemma. Biochem. Biophys. Res. Comm., 80, 936–941 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; and Randall, R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265–275 (1951).

    PubMed  CAS  Google Scholar 

  • McBroom, M. J.; and Welty, J. D. Effects of taurine on heart calcium in the cardiomyopathic hamster. J. Mol. Cell. Cardiol., 9, 853–858 (1977).

    Article  PubMed  CAS  Google Scholar 

  • McNamara, D. B.; Sulakhe, P. V.; Singh, J. N.; and Dhalla, N. S. Properties of heart sarcolemmal Na+-K+ ATPase. J. Biochem., 75, 795–803 (1974).

    PubMed  CAS  Google Scholar 

  • Nadkarni, B. B.; Hunt, B.; and Heggtveit, H. A. Early ultrastructure and biochemical changes in myopathic hamster heart. In Myocardiology, Vol. 1, E. Bajusz and G. Rona, eds. University Park Press, Baltimore (1972), pp. 251–261.

    Google Scholar 

  • Nayler, W. G. Significance of calcium ions in cardiac excitation and contraction. Am. Heart J., 65,404–411 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Olson, R. E. Myocardial metabolism in congestive heart failure. J. Chronic Diseases, 9, 442–464 (1959).

    Article  CAS  Google Scholar 

  • Peng, C. F.; Kane, J. J.; Murphy, M. L.; and Straub, K. D. Abnormal mitochondrial oxidative phosphorylation of ischemic myocardium reversed by Ca+2 chelating agents. J. Mol. Cell. Cardiol, 9, 897–908 (1977).

    Article  PubMed  CAS  Google Scholar 

  • Peterson, M. B.; Mead, R. J.; and Welty, J. D. Free amino acids in congestive heart failure. J. Mol. Cell. Cardiol., 5, 139–147 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Racker, E.; Knowles, A. F.; and Eytan, E. Resolution and reconstitution of ion transport systems. Ann. N.Y. Acad. Sci., 264, 17–33 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Read, W. O.; and Welty, J. D. Effect of taurine on epinephrine and digoxin induced irregularities of the dog heart. J. Pharm. Exptl. Ther., 139, 283–289 (1963).

    CAS  Google Scholar 

  • Reuter, H. Exchange of calcium ions in the mammalian myocardium: Mechanisms and physiological significance. Circ. Res., 34, 599–605 (1974).

    PubMed  Google Scholar 

  • Reynafarje, B.; and Lehninger, A. L. High affinity and low affinity binding of calcium by rat liver mitochondria. J. Biol. Chem., 244, 584–593 (1969).

    PubMed  CAS  Google Scholar 

  • St. Louis, P. J.; and Sulakhe, P. V. Adenosine triphosphate-dependent calcium binding and accumulation by guinea pig cardiac sarcolemma. Can. J. Biochem., 54, 946–956 (1976).

    Article  Google Scholar 

  • Selwyn, H. J.; Dawson, A. P.; and Dunnett, S. J. Calcium transport in mitochondria. FEBS Letters, 10, 1–5 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Sonnenblick, E. H.; and Stam, A. C, Jr. Cardiac muscle: Activation and contraction. Ann. Rev. Physiol, 31, 647–674 (1969).

    Article  CAS  Google Scholar 

  • Sperelakis, N.; and Schneider, J. A. A metabolic control mechanism for calcium ion influx that may protect the ventricular myocardial cell. Am. J. Cardiol, 37, 1079–1085 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Sulakhe, P. V.; and Dhalla, N. A. Excitation-contraction coupling in heart: VII. Calcium accumulation in subcellular particles in congestive heart failure. J. Clin. Invest., 50, 1019–1027 (1971a).

    Article  PubMed  CAS  Google Scholar 

  • Sulakhe, P. V.; and Dhalla, N. S. VI. Demonstration of calcium activated ATPase in the dog heart sarcolemma. Life Sci, 10, 185–191 (1971b).

    Article  CAS  Google Scholar 

  • Sulakhe, P. V.; Leung, N. L.; and St. Louis, P. J. Stimulation of calcium accumulation in cardiac sarcolemma by protein kinase. Can. J. Biochem., 54, 438–445 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Taussky, H. H.; and Shorr, E. A microcolorimetric method for the determination of inorganic phosphorus. J. Biol. Chem., 202, 675–685 (1953).

    PubMed  CAS  Google Scholar 

  • Tomlinson, C. W.; Yates, J. C; and Dhalla, N. S. Relationship among changes in intracellular calcium stores, ultrastructure and contractility of myocardium. In Myocardial Biology, Vol. 4, N. S, Dhalla, ed. University Park Press, Baltimore (1974), pp. 331–345.

    Google Scholar 

  • Welty, J. D.; and Read, W. O. Studies on some cardiac effects of taurine. J. Pharm. Exptl. Ther., 144, 110–155 (1964).

    CAS  Google Scholar 

  • Welty, J. D.; McBroom, M. J.; Appelt, A. W.; Peterson M. B.; and Read, W. O. Effect of taurine on heart and brain electrolyte imbalances. In Taurine, R. Huxtable and A. Barbeau, eds. Raven Press, New York (1976), pp. 155–163.

    Google Scholar 

  • Wollenberger, A. The energy metabolism of the failing heart and the metabolic action of the cardiac glycosides. J. Pharm. Exptl Ther., 97, 311–352 (1949).

    CAS  Google Scholar 

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Authors
  1. Joseph D. Welty
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  2. M. Cathie Welty
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Editor information

Editors and Affiliations

  1. Department of Physiology and Biophysics, Hahnemann Medical College, Philadelphia, USA

    S. W. Schaffer Ph.D.

  2. Department of Pharmacology, Medical College of Pennsylvania, Philadelphia, USA

    Steven I. Baskin Ph.D.

  3. Department of Pharmacology, Jefferson Medical College, Philadelphia, USA

    James J. Kocsis Ph.D.

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© 1981 Spectrum Publications, Inc.

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Welty, J.D., Welty, M.C. (1981). Effects of Taurine on Subcellular Calcium Dynamics in the Normal and Cardiomyopathic Hamster Heart. In: Schaffer, S.W., Baskin, S.I., Kocsis, J.J. (eds) The Effects of Taurine on Excitable Tissues. Monographs of the Physiological Society of Philadelphia, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8093-8_22

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  • DOI: https://doi.org/10.1007/978-94-009-8093-8_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8095-2

  • Online ISBN: 978-94-009-8093-8

  • eBook Packages: Springer Book Archive

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