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Gout and crystal deposition arthritis

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Part of the Problems in Practice Series book series (PRIP, volume 4)

Abstract

Certain types of joint pain, effusions and arthritis are now recognized to be a result of crystal deposition in the synovial membrane. Apparently the crystals attract immunoglobulins to their negatively charged surfaces and thereby initiate an inflammatory reaction in the joint. While most cases of chondrocalcinosis are idiopathic, we are beginning to discover a metabolic or endocrine basis for the deposition of these crystals. Of course, it has been known for some time that urate crystals, formed as a result of hyperuricaemia — either as a primary metabolic error in which excessive uric acid is formed or secondary to excessive production or insufficient excretion of urate — are responsible for gouty attacks. More recently, various types of arthritis due to deposition of calcium salts have been recognized; the acute varieties which very much resemble classical gout are called pseudogout.

Keywords

Uric Acid Serum Uric Acid Calcium Oxalate Serum Uric Acid Level Crystal Deposition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© D. N. Golding 1981

Authors and Affiliations

  1. 1.Princess Alexandra HospitalHarlow, EssexEngland
  2. 2.East Herts/West Essex HospitalsEngland

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