Abstract
Current problems in cardiac surgery have led us to study events at the level of the single cardiac cell. At present those patients with the best functional hearts are selected for surgery. The range of patients could usefully be extended either if we could protect a high risk system, where spontaneous myocardial work is unlikely to be resumed after surgery, or if we knew how to prepare the poorer prognosis patients biochemically for successful surgery. Secondly, increasing use of successful organ grafts requires the longest maintenance interval between excision and implant of the donor heart. Optimum conditions for organ graft survival have yet to be established.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Van Breeman, V. L. (1953). Intercalated discs in heart muscle studied with the electron microscope. Anat. Rec., 117, 49
Sjostrand, F. S. and Andersson, E. (1954). Electron microscopy of the intercalated discs of cardiac muscle tissue. Experientia, 10, 369
Price, K. C., Weiss, J. M., Hata, D. and Smith, J. R. (1955). Experimental needle biopsy of the myocardium of dogs with particular reference to histologic study by electron microscopy. J. Exp. Med., 101, 687
Muir, A. R. (1957). An electron microscope study of the embryology of the intercalated disc in the heart of the rabbit. J. Biochem. Biophys. Cytol., 3, 193
Muir, A. R. (1967a). The effects of divalent cations on the ultrastructure of the perfused rat heart J. Amt., 101, 239
Muir, A. R. (1967b). A calcium-induced contracture of cardiac muscle cells. Proc. Anat. Soc., 102, 148
Yokoyama, H. A., Jennings, B. B. and Wartman, W. B. (1961). Intercalated disks of dog myocardium. Exp. Cell. Res., 23, 29
Muir, A. R., (1965). Further observations on the cellular structure of cardiac muscle. J. Anat., 99, 27
Gould, R. P. and Powell, T. (1972). Intact isolated muscle cells from the adult rat heart. J. Physiol., 225, 16P
Powell, T. (1979). Isolation of cells from adult mammalian myocardium. J. Mol. Cell. Cardiol., 11, 511
Farmer, B. B., Harris, R. A., Jolly, W. W., Hathway, D. R., Katzberg, A., Watanabe, A. M., Whitlow, A. L. and Besche, H. R. (1977). Isolation and characterisation of adult rat heart cells. Arch. Biochem. Biophys. 179, 545
Clark, M. G., Gannon, B. J., Bodkin, N., Patten, G. S. and Berry, M. N. (1978). An improved procedure for the high-yield preparation of intact beating heart cells from the adult rat. Biochemical and morphological study. J. Mol. Cell. Cardiol., 10, 1101
Powell, T., Steen, E. M., Twist, V. W. and Woolf, N. (1978). Surface characteristics of cells isolated from adult rat myocardium. J. Mol. Cell. Cardiol., 10, 287
Morales, A. R., Fine, G. and Taber, R. E. (1967). Cardiac surgery and myocardial necrosis. Arch. Path., 83, 71
Brooks, W. W., Sturckow, B. and Bing, O. H. L. (1974). Myocardial hypoxia and reoxygenation, electrophysiologic and mechanical correlates. Am. J. Physiol. 226, 523
Dhalla, N. S., Yates, J. C., Walz, D. A., McDonald, V. A. and Olson, R. E. (1972). Correlation between changes in the endogenous energy stores and myocardial function due to hypoxia in the isolated perfused rat heart. Canad. J. Physiol. Pharmacol., 50, 333
Hatt, P. Y. and Moravec, J. (1971). Acute hypoxia of the myocardium. Ultrastructural changes. Cardiology, 56, 73
Hanson, J. and Huxley, H. E. (1953). Structural basis of the cross-striations in muscle. Nature, 172, 530
Lymn, R. W. and Taylor, E. W. (1971). Mechanism of adenosine triphosphate hypoxia and hypothermia on the release of lysosomal enzymes in the fog heart.
Huxley, A. F. and Niedergerke, R. (1954). Structural changes in muscle during contraction. Nature, 173, 971
Huxley, H. E. (1971). The structural basis of muscular contraction. Proc. Roy. Soc. London. B., 178, 131
Huxley, H. E. and Hanson, J. (1954). Changes in the cross-striations of muscle during contraction and stretch and their structural interpretation. Nature, 173, 973
Leighty, E. G., Ressallat, M. M., Passananti, G. T. and Sirak, H. D. (1966). Effects of hypoxia and hypothermia on the release of pysosomal enzymes in the dog heart. Surgical Forum, 27, 181
Decker, R. S., Poole, A. R., Griffin, E. E., Dingle, J. T. and Wildernthal, K. (1977). Altered distribution of lysosomal cathepsin D in ischaemic myocardium. J. Clin. Invest. 59, 911
Murakami, U. and Uchida, K., (1978). Purification and characterisation of a myosin-cleaving protease from rat heart myofibrils. Biochim. Biophys. Acta. 525, 219
Ekblom, B. and Bing, O. H. L. (1975). Tolerance of isolated cardiac muscle to hypoxia: Force-frequency interrelationships. Proc. Soc. Exp. Biol. Med., 148, 484
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1981 MTP Press Limited
About this chapter
Cite this chapter
Dow, J.W., Walker, E.J. (1981). Features of cardiac myocytes in culture: characterisation of the failing cell. In: Longmore, D.B. (eds) Towards Safer Cardiac Surgery. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8048-8_25
Download citation
DOI: https://doi.org/10.1007/978-94-009-8048-8_25
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-8050-1
Online ISBN: 978-94-009-8048-8
eBook Packages: Springer Book Archive