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Coordination Chemistry of the Siderophores and Recent Studies of Synthetic Analogues

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The Biological Chemistry of Iron

Part of the book series: NATO Advanced Study Institutes Series ((ASIC,volume 89))

Abstract

For the past ten years we have studied the coordination chemistry of microbial iron transport compounds, called siderophores, and structurally related synthetic analogues. Our research has included X-ray structure determinations (1–3), electrochemical studies (4), isomer assignment by spectrophotometry techniques (5), potentiometric titrimetry (6), and, most recently, kinetic measurements of the rates of iron exchange between siderophores (7). This work has helped to elucidate the chemical details of microbial iron transport, as well as to provide information for the logical design of chelating agents for the treatment of iron overload in humans. This paper will focus on a review of results obtained in the latter three areas of study.

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Author information

Authors and Affiliations

  1. Department of Chemistry, University of California, Berkeley, California, 94720, USA

    Kenneth N. Raymond & Thomas P. Tufano

Authors
  1. Kenneth N. Raymond
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  2. Thomas P. Tufano
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Editor information

Editors and Affiliations

  1. Dept. of Chemistry, University of Alberta, Edmonton, Canada

    H. Brian Dunford

  2. Dept. of Chemistry, University of British Columbia, Vancouver, Canada

    David Dolphin

  3. Dept. of Chemistry, University of California, Berkeley, USA

    Kenneth N. Raymond

  4. Dept. of Molecular Structure, University of Washington, Seattle, USA

    Larry Sieker

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© 1982 D. Reidel Publishing Company

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Raymond, K.N., Tufano, T.P. (1982). Coordination Chemistry of the Siderophores and Recent Studies of Synthetic Analogues. In: Dunford, H.B., Dolphin, D., Raymond, K.N., Sieker, L. (eds) The Biological Chemistry of Iron. NATO Advanced Study Institutes Series, vol 89. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7882-9_6

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  • DOI: https://doi.org/10.1007/978-94-009-7882-9_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7884-3

  • Online ISBN: 978-94-009-7882-9

  • eBook Packages: Springer Book Archive

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