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Occurrence of Infections and Antibiotic Prophylaxis in Non-Surgical Patients

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Book cover Evaluation and Management of Hospital Infections

Part of the book series: New Perspectives in Clinical Microbiology ((NPCM,volume 5))

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Abstract

The present paper concerns the occurrence and prophylaxis of hospital infections in patients whose humoral and/or cellular immunity is compromised. Of all the patients who are candidates for any kind of antibiotic prophylaxis not related to surgical treatment (Table I), this group runs the highest risk of becoming infected in the hospital. Because antibiotic prophylaxis in these patients cannot be evaluated apart from the other preventive measures taken concomitantly, prophylaxis will be discussed as a whole.

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References

  1. Bodey, G.P. 1970. Epidemiological studies of Pseudomonas species in patients with leukaemia. Am. J. Med. Sci. 260: 82.

    Article  PubMed  CAS  Google Scholar 

  2. Gurwith, M.J., Brunton, I.L., et al. 1978. Granulocytopenia in hospitalized patients. I. Prognostic factors and etiology of fever. Am. J. Med. 64: 121.

    Article  PubMed  CAS  Google Scholar 

  3. Schirnpff, S.C., Moody, II., Young, V.M. 1970. Relationship of colonization with Pseudomonas aeruginsa to development of pseudomonas bacteremia in cancer patients. Antimicrob. Agents Chemother. 4: 240.

    Google Scholar 

  4. Schirnpff, S.C., Young, V.M., et al. 1972. Origin of infection in acute non-lymphocytic leukaemia. Significance of hospital acquisition of potential pathogens. Ann. Intern. Med. 77: 707.

    Google Scholar 

  5. Levine, A.S., Schirnpff, S.C., Graw, R.G., Young, R.C. 1974. Hematologic malignancies and other marrow failure states: Progress in the management of complicating infections. Semin. Hematol. 11: 141.

    PubMed  CAS  Google Scholar 

  6. Nauta, E.H. 1979. Infection in the compromised host. In: G. Dick (ed.), Immunological aspects of infectious diseases. MTP Press Ltd., Lancaster.

    Google Scholar 

  7. Williams, D.M., Krick, J.A., Remington, J.S. 1976. Pulmonary infection in the compromised host. Am. Rev. Respir. Dis. 114: 359 (Part I) and 593 (Part II).

    PubMed  CAS  Google Scholar 

  8. Meer van der, J.W.M., Broek van den, P.J. 1979. Infections in compromised patients. Diagnosic aspects. Neth. J. Med. 22: 108.

    PubMed  Google Scholar 

  9. Valdivieso, M. 1976. Bacterial infection in haematological diseases. Clin. Haematol. 5: 229.

    PubMed  CAS  Google Scholar 

  10. Bodey, G.P., Buckley, M., et al. 1966. Quantitative relationships between circulating leukocytes and infection in patients with acute leukaemia. Ann. Intern. Med. 64: 3 28.

    Google Scholar 

  11. Meer van der, J.W.M., Alleman, M., Boekhout, M. 1979. Infectious episodes in severely granulocytopenic patients. Infection 7: 171.

    Article  PubMed  Google Scholar 

  12. Hart, P.D., Russell, E., Remington, J.S. 1969. The compromised host and infection. ±1. Deep fungal infection. J. Inf. Dis. 120: 169.

    Google Scholar 

  13. Baker, R.D. 1962. Leukopenia and therapy in leukaemia as factors predisposing to fatal mycoses. Am. J. Clin. Pathol. 37: 358.

    Google Scholar 

  14. Colpin, G.G.D., Guiot, H.F.L., 1981. Bacillus cerius meningitis in a patient under gnotobiotic care. Lancet ii: 694.

    Google Scholar 

  15. Price, D.J.E., Heigh, J.D. 1970. Control of infection due to Klebsiella aerogenes in a neurosurgical unit by withdrawal of all antibiotics. Lancet ii: 1213.

    Google Scholar 

  16. Greene, W.H., Schirnpff, S.C., et al. 1973. Empiric carbeniciliin gentamicin and cephalotin therapy for presumed infection in patients with granulocytopenia and cancer. Ann. Intern. Med. 78: 825.

    Google Scholar 

  17. Schirnpff, S.C. 1977. Therapy of infection in patients with granulocytopenia. Med. Clin. North Am. 61: 1101.

    Google Scholar 

  18. Pollac, M., Charache, P. 1972. Factors influencing colonization and antibiotic-resistance patterns of Gramnegative bacteria in hospital patients. Lancet ii: 668.

    Google Scholar 

  19. Pennington, J.E. 1977. Fever, neutropenia and malignancy: a clinical syndrome in evolution. Cancer 39: 1345.

    Article  PubMed  CAS  Google Scholar 

  20. Broek van der, P.J., Meer van der, J.W.M. 1979. Antimicrobial therapy in the myelo- and immunocompromised patient. Neth. J. Med. 22: 118.

    Google Scholar 

  21. Strauss, R.G., Connett, J.E., et al. 1981. A controlled trial of prophylactic granulocyte transfusions during initial induction chemotherapy for acute myelogenous leukaemia. N. Engl. J. Med. 305: 597.

    Google Scholar 

  22. Jones, R.J. 1981. Vaccines and antisera against Gramnegative bacilli. J. Hosp. Infect. 2: 105.

    Google Scholar 

  23. Hughes, W.T., Kuhn, S., et al. 1977. Successful chemoprophylaxis for Pneumocystis carinii pneumonitis. N. Engl. J. Med. 297: 1419.

    Google Scholar 

  24. McLaughlin, M.M., Dacquisito, M.P., et al. 1964. Effects of the germfree state on responses of mice to whole-body irradiation. Radiat. Res. 23: 333.

    Google Scholar 

  25. Levine, A.S. Siegel, S.E. 1973. Protected environments and prophylactic antibiotics. A prospective controlled study of their utility in the therapy of acute leukaemia. N. Engl. J. Med. 288: 477.

    Google Scholar 

  26. Schirnpff, S.C., Green, W.H., et al. 1975. Infection prevention in acute non-lymphocytic leukaemia. Laminar airflow room reverse isolation with oral, non-absorbable antibiotic prophylaxis. Ann. Intern. Med. 82: 351.

    Google Scholar 

  27. Bodey, G.P., Rosenbaum, B. 1974. Effect of prophylactic measures on the microbial flora of patients in protected environment units. Medicine 53: 209.

    Article  PubMed  CAS  Google Scholar 

  28. Bodey, G.P., Rodriques, V. 1975. Infections in cancer patients on a protected environment. Prophylactic antibiotic program. Am. J. Med. 59: 497.

    Google Scholar 

  29. Rodriquez, V., Bodey, G.P., et al. 1978. Randomized trial of protected environment. Prophylactic antibiotics in 145 adults with acute leukaemia. Medicine 57: 253.

    Google Scholar 

  30. Waay van der, D., Berghuis-de Vries, J.M., Lekkerkerk-Wees van der, J.E.C. 1971. Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. J. Hyg. ( Camb. ) 69: 405.

    Google Scholar 

  31. Waay van der, D., Berghuis, J.M. 1974. Determination of the colonization resistance of the digestive tract of individual mice. J. Hyg. ( Camb. ) 72: 379.

    Google Scholar 

  32. Wulff, H.R. 1981. Rational diagnosis and treatment. Second edition. Blackwell Scientific Publications. Oxford, London, Edinburgh, Melbourne.

    Google Scholar 

  33. Lowbury, E.I.L., Babb, I.R., Ford, P.M. 1971. Protective isolation in a burns unit: The use of plastic isolators and air curtains. J. Hyg. ( Camb. ) 69: 529.

    Google Scholar 

  34. Cason, J.S., Jackson, D.M., et al. 1966. Antiseptic and aseptic prophylaxis for burns: Use of silver nitrate and of isolators. Br. Med. J. IV: 1288.

    Google Scholar 

  35. Lidwell, O.M., Towers, A.G. 1972. Unidirectional (“laminar”) flow ventilation system for patient isolation. Lancet i: 347.

    Google Scholar 

  36. Winner, H.I., Bagshawe, K.D., et al. 1970. Microbiological aspects of cytotoxic drug therapy. Proc. R. Soc. Med. 63: 28.

    Google Scholar 

  37. Jameson, B., Gamble, R., et al. 1971. Five-year analysis of protective isolation. Lancet i: 1034.

    Google Scholar 

  38. Yates, J.W., Holland, J.F. 1973. A controlled study of isolation and endogenous microbial suppression in acute myelocytic leukaemia patients. Cancer 32: 1490.

    Article  PubMed  CAS  Google Scholar 

  39. Dietrich, M., Gaus, W., et al. 1977. Protective isolation and antimicrobial decontamination in patients with high susceptibility to infection. Infection 5: 107.

    Article  PubMed  CAS  Google Scholar 

  40. Nauseef, W.M., Maki, D.G. 1981. A study of the value of simple protective isolation in patients with granulocytopenia. N. Engl. J. Med. 304: 448.

    Google Scholar 

  41. Hahn, D.M., Schirnpff, S.C., et al. 1978. Infection in acute leukaemia patients receiving oral non-absorbable antibiotics. Antimicrob. Agents Chemother. 13: 958.

    Google Scholar 

  42. Bender, J.F., Schirnpff, S.C., et al. 1979. Role of vancomycin as a component of oral non-absorbable antibiotics for microbial suppression in leukaemic patients. Antimicrob. Agents Chemother. 15: 455.

    Google Scholar 

  43. Mulder, N.H., Nieweg, H.O., 1979. Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract. In: D. van der Waay and J. Verhoef (eds). New criteria for antimicrobial therapy. Excerpta Medica. Amsterdam, Oxford. 113.

    Google Scholar 

  44. Dekker, A.W., Rozenberg-Arska, M., et al. 1981. Prevention of infection by trimethoprim-sulfamethoxazole plus amphotericin B in patients with acute non-lymphocytic leukaemia. Ann. Intern. Med. 95: 555.

    Google Scholar 

  45. Wade, J.C., Schirnpff, S.C., et al. 1981. A comparison of trimethoprim-sulfamethoxazole plus nystatin with gentamicin plus nystatin in the prevention of infections in acute leukaemia. N. Engl. J. Med. 304: 1057.

    Google Scholar 

  46. Gurwith, M.J., Trong, K. 1979. A comparison of prophylactic trimethoprim/sulfamethoxazole to trimethoprim alone in compromised hosts. Abstracts 11th ICC and 19th ICAAC, Boston, Massachusetts, U.S.A. Abstract 70.

    Google Scholar 

  47. McNaughton, R.D., Riben, P., et al. 1979. A comparison of trimethoprim and trimethoprim/sulfamethoxazole prophylaxis in neutropenic patients. The elimination of potential pathogens and the emergence of resistance. Abstracts 11th ICC and 19th ICAAC, Boston, Massachusetts, U.S.A. Abstract 69.

    Google Scholar 

  48. Guerrant, R.L., Wood, S.J., et al. 1981. Resistance among fecal flora of patients taking sulfamethoxazole-trimethoprim or trimethoprim alone. Antimicrob. Agents Chemother. 19: 33.

    Google Scholar 

  49. Storring, R.A., Jameson, B. 1977. Oral non-absorbed antibiotics prevent infection in acute non-lymphoblastic leukaemia. Lancet ii: 837.

    Google Scholar 

  50. Enno, A., Catovsky, D. 1978. Cotrimoxazole for prevention of infection in acute leukaemia, lancet ii: 395.

    Google Scholar 

  51. Watson, J.G., Jameson, B., et al. 1982. Cotrimoxazole versus non-absorbable antibiotics in acute leukaemia. Lancet i: 6.

    Google Scholar 

  52. Gurwith, M.J., Brunton, J.C., et al. 1979. A prospective controlled investigation of prophylactic trimethoprim/ sulfamethoxazole in hospitalized granulocytopenic patients. Am. J. Med. 66: 248.

    Google Scholar 

  53. Starke, I.D., Donnelly, P.. 1982. Cotrimoxazole alone for prevention of bacterial infection in patients acute leukaemia. Lancet i: 5.

    Google Scholar 

  54. Guiot, H.F.L., Furth van, R. 1977. Partial antibiotic decontamination. Br. Med. J. I: 800.

    Google Scholar 

  55. Guiot, H.F.L., Meer van der, J.W.M., Furth van, R. 1981. Selective antimicrobial modulation of human microbial flora. Infection prevention in patients with decreased host defense mechanisms by selective elimination of potentially pathogenic bacteria. J. Infect. Dis. 143: 644.

    Google Scholar 

  56. Guiot, H.F.L., Broek van den, P.J., Meer van der, J.W.M., et al. 1982. Selective antimicrobial modulation of the intestinal flora as measure for infection prevention in patients with acute non-lymphocytic leukaemia. Submitted for publication.

    Google Scholar 

  57. Preisler, H.D., Goldstein, I.M., Henderson, E.S. 1970. Gastro-intestinal “sterilization” in the treatment of patients with acute leukaemia. Cancer 26: 1076.

    Article  PubMed  CAS  Google Scholar 

  58. Bodey, G.P., Gehan, E.A., et al. 1971. Protected environment prophylactic antibiotic program in the chemotherapy of acute leukaemia. Am. J. Med. Sci. 262: 138.

    Google Scholar 

  59. Rodriquez, V., Bodey, G.P., et al. 1978. Randomized trial of protected environment-prophylactic antibiotics in 145 adults with acute leukaemia. Medicine 57: 253.

    Google Scholar 

  60. Lohner, D., Debusscher, L., et al. 1979. Comparitive randomized study of protected environment plus oral antibiotics versus oral antibiotics alone in neutropenic patients. Cancer Treat. Rep. 63: 363.

    Google Scholar 

  61. Dietrich, M., Rasche, H., et al. 1973. Antimicrobial therapy as a part of the decontamination procedures for patients with acute leukaemia. Eur. J. Cancer 9: 443.

    Google Scholar 

  62. Moorhouse, E.C., Farrell, W. 1972. Effect of cotrimoxazole on faecal enterobacteria. No emergence of resistant strains. J. Med. Microbiol. 6: 249.

    Article  Google Scholar 

  63. Speller, D.C.E., Braten, D.M. 1972. Faecal flora after prolonged cotrimoxazole treatment. Br. Med. J. II: 416.

    Article  Google Scholar 

  64. Knothe, H. 1973. The effect of a combined preparation of trimethoprim and sulphamethoxazole following short-term and long-term administration on the flora of the human gut. Chemotherapy 18: 285.

    Article  PubMed  CAS  Google Scholar 

  65. Mihara, G., Stamey, T.A. 1979. The effect of low-dose cotrimoxazole (trimethoprim-sulfamethoxazole) on rectal and vaginal flora. In: D. van der Waaij and J. Verhoef (eds) New criteria for antimicrobial therapy. Excerpta Medica. Amsterdam, Oxford. 243.

    Google Scholar 

  66. Murray, B.E., Rensimer, E.R., DuPont, H.L. 1982. Emergence of high-level trimethoprim resistance in fecal Escherichia coli during oral administration of trimethoprim or trimethoprim-sulfamethoxazole. N. Engl. J. Med. 306: 130.

    Article  PubMed  CAS  Google Scholar 

  67. Wilson, I.M., Guiney, D.G., 1982. Failure of oral trimethoprim-sulfamethoxazole prophylaxis in acute leukaemia. Isolation of resistant plasmids from strains of enterobacteriaceae causing bacteremia. N. Engl. J. Med. 306: 16.

    Article  PubMed  CAS  Google Scholar 

  68. Jacoby, G.A., 1982. Perils of prophylaxis (editorial). N. Engl. J. Med. 306: 43.

    Article  PubMed  CAS  Google Scholar 

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© 1982 Martinus Nijhoff Publishers, The Hague

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Van Den Broek, P.J., Fibbe, W.E. (1982). Occurrence of Infections and Antibiotic Prophylaxis in Non-Surgical Patients. In: Van Furth, R. (eds) Evaluation and Management of Hospital Infections. New Perspectives in Clinical Microbiology, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7657-3_14

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  • DOI: https://doi.org/10.1007/978-94-009-7657-3_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7659-7

  • Online ISBN: 978-94-009-7657-3

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