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Morphologic Assessment of Cardiac Lesions Caused by Anthracyclines

  • Chapter
Anthracycline Antibiotics in Cancer Therapy

Part of the book series: Developments in Oncology ((DION,volume 10))

Abstract

The clinical use of daunorubicin and doxorubicin, two anti-neoplastic drugs of the anthracycline family, has been limited by the development of cardiotoxic effects. These can be subdivided into acute, subacute and chronic depending upon their temporal relationship to the administration of the drugs. The acute effects consist of hypotension, tachycardia and various arrhythmias, which develop within minutes after intravenous administration. The subacute effects are characterized by fibrinous pericarditis or myocardial dysfunction, which occur within four weeks of the first or second dose of the drug. The chronic effects develop only after several weeks or months of treatment, sometimes after the course of therapy has been completed, and are manifested by the insidious onset of severe, often fatal congestive heart failure.

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Authors
  1. V. J. Ferrans
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Editor information

Editors and Affiliations

  1. New York University Medical Center, New York, New York, 10016, USA

    Franco M. Muggia

  2. Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, USA

    Charles W. Young

  3. Northern California Oncology Group, Palo Alto, California, 94304, USA

    Stephen K. Carter

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© 1982 Martinus Nijhoff Publishers, The Hague

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Ferrans, V.J. (1982). Morphologic Assessment of Cardiac Lesions Caused by Anthracyclines. In: Muggia, F.M., Young, C.W., Carter, S.K. (eds) Anthracycline Antibiotics in Cancer Therapy. Developments in Oncology, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7630-6_30

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  • DOI: https://doi.org/10.1007/978-94-009-7630-6_30

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7632-0

  • Online ISBN: 978-94-009-7630-6

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