Abstract
Herrick in 1910 gave the first known published description of renal involvement, although sickle cell disease had long been recognized in West Africa (1,2). He described “peculiarly elongated and sickle-shaped” red blood cells in a young black student from Grenada with anemia, white blood cells and casts in the urine, slightly increased urine output, and low urinary specific gravity. In the following years, a number of studies described the renal functional and structural abnormalities in such patients. Although the term sickle cell nephropathy has been used to describe many of the renal lesions found in patients with sickle cell disorders, recently it has been most often limited to the setting of proteinuria with predominantly glomerular lesions; Friedman et al. (3) imply that it may represent a state of life-threatening renal failure. It is only recently that the study of these lesions gained momentum in comparison to the massive body of literature related to hematuria and the disordered concentrating ability and hemodynamics. Excellent reviews of the general and renal aspects of these disorders have been published (2,4-6).
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References
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Vaamonde, C.A. (1982). Sickle Cell Nephropathy. In: Strauss, J. (eds) Hypertension, Fluid-Electrolytes, and Tubulopathies in Pediatric Nephrology. Developments in Nephrology, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7541-5_7
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DOI: https://doi.org/10.1007/978-94-009-7541-5_7
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