Abstract
The study of tubular reabsorption of water and sodium becomes very important in the functional examination of patients with renal tubular disorders. These human studies are limited to the application of clearance methods, which although less sophisticated than modern experimental techniques, retain the unique advantage of being relevant to the whole kidney “in situ” rather than to an isolated population of nephrons. When fractional clearances are calculated under conditions of hypotonic saline diuresis, a functional assessment of tubular handling of water and sodium becomes possible (1,2). This brief review examines the physiological basis of such clearance methodology, describes the experimental protocol and summarizes results in health and disease.
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© 1982 Martinus Nijhoff Publisher, The Hague
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Rodriguez-Soriano, J., Vallo, A. (1982). Clearance Methodology in the Study of Tubular Handling of Water and Sodium. In: Strauss, J. (eds) Hypertension, Fluid-Electrolytes, and Tubulopathies in Pediatric Nephrology. Developments in Nephrology, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7541-5_6
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DOI: https://doi.org/10.1007/978-94-009-7541-5_6
Publisher Name: Springer, Dordrecht
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