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Inflammatory Bowel Diseases pp 27–40Cite as

Dysplasia and Carcinoma in Inflammatory Bowel Disease

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Part of the book series: Developments in Gastroenterology ((DIGA,volume 3))

Abstract

Chronic inflammatory conditions often serve as promoting factors for the development of malignant tumors. Within the intestinal tract, enhanced carcinoma formation has been recorded in chronic infections such as tuberculosis and schistosomiasis and especially in cases of inflammatory bowel disease (IBD), including both ulcerative colitis (UC) and Crohn’s disease (CD). The dominant precursor lesion of colonic adenocarcinoma in the general population is the adenomal,2, but it has been estimated that about 1000 or 1 percent of all new cases of carcinoma in USA arise as a complication of chronic IBD3. Although these colitis-related tumors provide only a small fraction, they more commonly afflict younger patients, behave in a more aggressive fashion, and it appears that the large majority can be prevented. The present review will concentrate on the identification of epithelial dysplasia and its use in determining which patients with chronic colitis are more apt to have or develop a carcinoma.

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Author information

Authors and Affiliations

  1. Department of Pathology, Beth Israel Hospital and Harvard Medical School, Boston, MA, USA

    Harvey Goldman M.D.

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  1. Harvey Goldman M.D.
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Editor information

Editors and Affiliations

  1. Hebrew University-Hadassah Medical School, Jerusalem, Israel

    Daniel Rachmilewitz M.D. (Associate Professor of Medicine) (Associate Professor of Medicine)

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© 1982 Martinus Nijhoff Publishers, The Hague

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Goldman, H. (1982). Dysplasia and Carcinoma in Inflammatory Bowel Disease. In: Rachmilewitz, D. (eds) Inflammatory Bowel Diseases. Developments in Gastroenterology, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7514-9_3

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  • DOI: https://doi.org/10.1007/978-94-009-7514-9_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-7516-3

  • Online ISBN: 978-94-009-7514-9

  • eBook Packages: Springer Book Archive

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