Abstract
It has recently been demonstrated that a great degree of specificity exists in the interaction of cells with their extracellular matrices [1, 2, 3]. Collagen, a major component of extracellular matrix, exists in at least five genetically distinct forms; type I and type III collagens are found in the stroma of many tissues [4], type II in cartilage [5] and type IV in basement membranes [6], While mesenchymal cells adhere to stromal collagens in vitro [1], epithelial cells show a specificity for type IV (basement membrane) collagen [2, 7]; that is, cells appear to adhere to the types of collagen with which they are normally in contact in vivo. In vitro these interactions are mediated by high molecular weight glycoproteins; mesenchymal cells utilize fibronectin to bind to all collagens [2], whereas epithelial cells adhere preferentially to type IV basement membrane collagen using laminin. In vivo, fibronectin appears as a major component of mesenchymal extracellular matrices [7], whereas laminin is a major component of basement membranes and is absent from other tissues [8, 9].
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References
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© 1982 Martinus Nijhoff Publishers, The Hague/Boston/London
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Murray, J.C., Liotta, L.A., Terranova, V.P. (1982). Attachment of metastatic tumor cells to collagen. In: Liotta, L.A., Hart, I.R. (eds) Tumor Invasion and Metastasis. Developments in Oncology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7511-8_18
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DOI: https://doi.org/10.1007/978-94-009-7511-8_18
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