Abstract
The HeLa cell line is derived from biopsy specimens of a patient with advanced uterine cervical cancer (Gey et al. 1952). Based on histological and autopsy findings, this cancer was initially identified as anaplastic epidermoid cancer (Leighton 1957). However, the origin of the HeLa cells was reappraised (Jones et al. 1971) and it was suggested that it was adenocarcinomatous with obvious glandular elements. Therefore, the establishment of a cell line derived from epidermoid cancer of the uterine cervix became desirable.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abell MR: Invasive carcinoma of uterine cervix. In Norris HJ, Hertig AT, Abell MR (eds): The uterus. Baltimore: The Williams & Wilkins Company, 1973, pp 413–56.
Arata T, Ogawa I, Tanaka Y, Hashimoto K: Transplantation of a newly established human cancer cell line. Gann 60: 649, 1969.
Fishman WH, Inglis NR, Stolbach LL, Krant MJ: A serum alkaline phosphatase isoenzyme of human neoplastic cell origin. Cancer Res 28 (1): 150, 1968.
Fishman WH: Carcinoplacental isoenzyme antigens. In Weber G (ed): Advances in enzyme regulation, Vol. XI. Oxford & New York: Pergamon Press, 1973, pp 293–321.
Friedl F, Kimura I, Osato T, Ito Y: Studies on a new human cell line (SiHa) derived from carcinoma of uterus. Its establishment and morphology. Proc Sci Exp Biol Med 135: 543, 1970.
Gey GO, Coffman WD, Kubicek MT: Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium. Cancer Res 12: 264, 1952.
Iino S, Abe K, Oda T, Suzuki H, Sugimura H: A new method of radioimmunoassay for human placental alkaline phosphatase. Clinica/Chimica Acta 42: 161, 1972.
Ishiwata I, Nozawa S, Nagai S, Kurihara S, Mikata A, Okumura H: Establishment of human leiomyosarcoma cell line. Cancer Res 37: 658, 19777a.
Ishiwata I, Nozawa S, Inoue T, Okumura H: Development and characterization of established cell lines from primary and metastatic regions of human endometrial adenocarcinoma. Cancer Res 37: 1777, 1977b.
Ishiwata I, Nozawa S, Kiguchi K, Kurihara S, Okumura H: Establishment of human uterine cervical cancer cell line and comparative studies between normal and malignant uterine cervical cells in vitro. Acta Obst Gynaec Jap 30: 731, 1978.
Jones HW, McKuick VA, Harper PS, Wuu KD: The Hela Cell and a reappraisal of its origin. Obstetrics and Gynecology 38: 945, 1971.
Leighton J: Contributions of tissue culture studies to an understanding of the biology of cancer: A review. Cancer Res 17: 929, 1957.
Littman P, Clement PB, Henriksen B, Wang CC, Robboy SJ, Taft PD, Ulfelder H, Scully RE: Glassy cell carcinoma of the cervix. Cancer 37: 2238, 1976.
Nakane PK, Kawaoi A: Peroxidase-labeled antibody. A new method of conjugation. J Histochem Cytochem 22 (12): 1084, 1974.
Nathanson L, Fishman WH: New observations on the Regan isoenzyme of alkaline phosphatase in cancer patients. Cancer 27 (6): 1388, 1977 ).
Novak ER, Woodruff JD: Cervical Neoplasia. In: Gynecologic and Obstetrics Pathology. Philadelphia: Saunders, 1979, pp 111–156.
Nozawa S, Izumi S, Ohta H, Shinozuka T, Tsutsui F, Kurihara S, Watanabe K: Histochemical studies on alkaline phosphatase in uterine cervical reserve cell, precancerous and cancerous lesions. In: Shanmugaratnan K et al. (eds): Proceedings of the 2nd Asian Cancer Conf. Singapore: Stanford College Press, 1975a, pp 324–326.
Nozawa S, Ishiwata I, Kiguchi K, Tguchi J, Tsukahara S, Kurihara S, Komatsu K, Okumura H: Electron microscopic studies on a newly established cell line of human endometrial adenocarcinoma. J Clin Electron Microscopy 8: 442, 1975b.
Nozawa S, Kiguchi K, Ishiwata I, Nagai S, Taguchi S, Tsukahara S, Tsutsui F, Tamura S, Kurihara S, Komatsu N, Okumura H: Electron microscopic studies on a newly established cell line of human uterine cervical cancer. J Clin Electron Microscopy 9: 606, 1976.
Nozawa S, Ohta H, Izumi S, Hayashi S, Tsutsui F, Kurihara S, Watanabe K: Heat-stable alkaline phosphatase in normal female genital organ - with special reference to the histochemical heat stability and L-phenylalanine inhibition test. Acta histochem cytochem 13 (5): 521, 1980.
Pattillo RA, Hussa RO, Story MT, Ruckert AC, Shalaby MR, Mattingly RF: Tumor antigen and human chorionic gonadotropin in CaSki cells: A new epidermoid cervical cancer cell line. Science 196: 1456, 1977.
Porter JC, Nalick RH, Vellios F, Neaves WB, MacDonald PC: New tissue culture cell lines derived from human squamous cell carcinoma of the cervix and vagina. Am J Obstet Gynecol 130: 487, 1978.
Stolbach LL, Krant MJ, Fishman WH: Ectopic production of an alkaline phosphatase isoenzyme in patients with cancer. Ann NY Acad Sci 166 (2): 760, 1969.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1982 Martinus Nijhoff Publishers
About this chapter
Cite this chapter
Nozawa, S. et al. (1982). Human Cell Line (SKG-1) Derived from Epidermoid Cancer of the Cervix. In: Hafez, E.S.E., Smith, J.P. (eds) Carcinoma of the Cervix. Developments in Obstetrics and Gynecology, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7485-2_22
Download citation
DOI: https://doi.org/10.1007/978-94-009-7485-2_22
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-7487-6
Online ISBN: 978-94-009-7485-2
eBook Packages: Springer Book Archive