Role of Changes in Na+ Transport in Cell Membranes in the Pathogenesis of Primary Hypertension

  • Philippe Meyer
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 16)


Experimental epidemiological and clinical studies show clearly that there exists a close relationship between primary hypertension and body sodium (Na+). The fact that the first investigators were oriented towards extracellular Na+ is not surprising when we consider the high concentration of this ion in the extracellular fluid volume, compared to the intracellular medium, as well the undisputable role of this body fluid compartment in the maintenance of arterial pressure. However, numerous studies have been unable to demonstrate any clear-cut increase in the extracellular fluid volume in essential hypertension, a result that would be expected if an increase in extracellular Na+ were involved [1].


Essential Hypertension Erythrocyte Membrane Sodium Transport Primary Hypertension Human Hypertension 
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© Martinus Nijhoff Publishers, The Hague 1982

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  • Philippe Meyer

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